PCORnet®: An Infrastructure Supporting Innovation in Clinical Study Design

Area of Science:

• Health Services Research
• Clinical Research Infrastructure
• Patient-Centered Outcomes Research

Background:

• PCORnet, funded by the Patient-Centered Outcomes Research Institute, is a national resource for efficient health research.
• The PCORnet infrastructure supports diverse study designs and serves as a model for patient-centered research.
• A subset of studies, PCORnet® Studies, meet specific criteria for quality and impact.

Purpose of the Study:

• To explore the utilization and impact of the PCORnet infrastructure over the past decade.
• To highlight study archetypes, clinical areas, funding, and institutional users within PCORnet.
• To identify lessons learned and unique capabilities for future research innovation.

Main Methods:

• Review of studies completed using the PCORnet infrastructure.
• Analysis of meritorious PCORnet® Studies based on defined criteria.
• Exploration of study characteristics including therapeutic areas and funding sources.

Main Results:

• Over 300 studies completed using PCORnet infrastructure in the last 10 years.
• 58 studies designated as meritorious PCORnet® Studies, with 19 completed.
• Diverse clinical areas and funding sources represented across PCORnet studies.

Conclusions:

• The PCORnet infrastructure effectively supports a wide range of patient-centered research.
• Accumulated experience provides lessons for a continuously learning research framework.
• PCORnet capabilities foster innovation for future clinical trials and research endeavors.