The Midas touch: Recombinant antibodies transforming diagnostic platforms

Antibodies, crucial for diagnostics due to their specific antigen-binding, can be identified using in vitro display technologies. Recombinant antibodies are a new generation of antibodies devoid of immunization thus eliminating the need for a host animal. However, the application of recombinant antibodies in diagnostics is still lagging in comparison to animal derived antibodies. This review will focus on the antibodies derived from phage display, a technology that presents antibodies on filamentous phage for selection. We explore its application and discuss derivative display systems, such as ribosome, yeast, bacterial, and mammalian cell display in recombinant antibody development. This review showcases the exciting potential of recombinant antibodies for diagnostic innovation.