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COVID-19 Infection vs Vaccination and the Risk of New-onset Psoriasis
Sophie L Preuß1, Henning Olbrich1, Katja Bieber2
1Department of Dermatology, University Medical Center of the State of Schleswig-Holstein (UKSH), Campus Lübeck, Lübeck, Germany.
Acta Dermato-Venereologica
|January 9, 2026
Summary
COVID-19 infection significantly increases the risk of developing new-onset psoriasis compared to vaccination. This study highlights infection as a potential trigger for psoriasis, supporting vaccine safety.
Area of Science:
- Dermatology
- Immunology
- Epidemiology
Background:
- Emerging evidence suggests a link between COVID-19 infection/vaccination and new-onset psoriasis.
- Previous findings were limited by small sample sizes and inadequate control groups.
Purpose of the Study:
- To compare the risk of new-onset psoriasis in COVID-19 infected individuals versus vaccinated individuals.
- To investigate the potential role of COVID-19 infection in psoriasis pathogenesis.
Main Methods:
- Retrospective cohort study using US electronic health records (TriNetX, Jan 2020-Jan 2025).
- Propensity score matching to balance demographics and comorbidities.
- Kaplan-Meier analysis and Cox proportional hazards models to compare outcomes.
Main Results:
- COVID-19 infection was associated with a significantly higher risk of new-onset psoriasis (HR 1.30; 95% CI, 1.14-1.49; p < 0.001).
- Increased risks observed for psoriatic arthritis and pustulosis palmaris et plantaris.
- No increased risk of psoriasis was found in vaccinated individuals compared to controls.
Conclusions:
- COVID-19 infection may play a triggering role in psoriasis development.
- COVID-19 vaccination demonstrates a favorable safety profile regarding psoriasis onset.
- Further research is needed to establish causality and inform clinical practice.
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