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Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
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Association Between Systemic Immune-Inflammation Index and Thyroid Function: A Cross-Sectional Population-Based

Jiaqi Huang1,2, Jieqiong Song3, Ming Zhong3

  • 1Department of Urology, Zhongshan Hospital, Fudan University, Shanghai, China, fudan.edu.cn.

International Journal of Endocrinology
|January 9, 2026
PubMed
Summary
This summary is machine-generated.

The systemic immune-inflammation index (SII) is linked to thyroid function in U.S. adults. Higher SII correlates with lower FT3 and TSH, and higher TT4, suggesting a connection between inflammation and thyroid health.

Keywords:
NHANEScross-sectional studysystemic immune-inflammation indexthyroid function

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Area of Science:

  • Endocrinology
  • Immunology
  • Public Health

Background:

  • The systemic immune-inflammation index (SII) is an emerging biomarker.
  • Its association with thyroid function is not well-established.
  • This study investigates the SII-thyroid function relationship in the U.S. population.

Purpose of the Study:

  • To examine the association between SII and key thyroid hormones.
  • To explore potential links between systemic inflammation and thyroid status.

Main Methods:

  • Cross-sectional analysis of NHANES 2007-2012 data.
  • Evaluation of SII with free triiodothyronine (FT3), free thyroxine (FT4), total triiodothyronine (TT3), total thyroxine (TT4), and TSH.
  • Utilized multiple linear regression, smooth curve fitting, and threshold effect analysis.

Main Results:

  • Higher SII levels were independently associated with lower FT3, TT3, and TSH.
  • Positive association found between SII and TT4 after full adjustment.
  • L-shaped relationship observed between SII and FT3/TSH, with an inflection point at lgSII = 2.29.

Conclusions:

  • Systemic inflammation, indicated by SII, is associated with thyroid function in U.S. adults.
  • Findings suggest a negative correlation with FT3 and TSH, and a positive correlation with TT4.
  • Further prospective research is needed to confirm causality.