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Updated: Jan 13, 2026

Recording Temperature-induced Neuronal Activity through Monitoring Calcium Changes in the Olfactory Bulb of Xenopus laevis

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Published on: June 3, 2016

Learning-dependent feedback by OLM interneurons shapes CA1 representations.

Evan P Campbell¹, Lisandro Martin², Jeffrey C Magee¹

¹Howard Hughes Medical Institute, Baylor College of Medicine, Houston, TX, 77030.

Biorxiv : the Preprint Server for Biology

|January 9, 2026

Summary

This summary is machine-generated.

Oriens lacunosum-moleculare (OLM) interneurons provide critical inhibitory feedback for spatial learning. These neurons regulate behavioral timescale synaptic plasticity (BTSP) and stabilize hippocampal place cell representations during learning.

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Last Updated: Jan 13, 2026

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Targeted Labeling of Neurons in a Specific Functional Micro-domain of the Neocortex by Combining Intrinsic Signal and Two-photon Imaging

Targeted Labeling of Neurons in a Specific Functional Micro-domain of the Neocortex by Combining Intrinsic Signal and Two-photon Imaging

Published on: December 12, 2012

Area of Science:

Neuroscience
Synaptic Plasticity
Hippocampal Function

Background:

Spatial learning relies on hippocampal CA1 place cell formation via behavioral timescale synaptic plasticity (BTSP).
BTSP is driven by dendritic Ca²⁺ plateau potentials, influenced by entorhinal cortex input and CA1 inhibitory feedback.
The cellular source of this crucial inhibitory feedback has remained unidentified.

Purpose of the Study:

To identify the specific interneurons providing inhibitory feedback during BTSP.
To investigate the role of OLM interneurons in regulating hippocampal representations during learning.

Main Methods:

In vivo two-photon calcium imaging to monitor neuronal activity.
Bidirectional optogenetic manipulation of OLM interneurons.
Combined electrophysiology and calcium imaging to assess synaptic plasticity and place cell formation.

Main Results:

OLM interneuron activity increased with learning and was spatially biased toward salient locations.
Optogenetic silencing of specific OLM interneurons late in learning enhanced dendritic plateaus and place cell formation.
Optogenetic activation of OLM interneurons early in learning suppressed plateau initiation and place field formation.

Conclusions:

OLM interneurons act as the key inhibitory feedback element regulating BTSP.
These interneurons dynamically control hippocampal representations, stabilizing them during spatial learning.