Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Plasticity00:58

Plasticity

3.1K
Plasticity is the property where an object loses its elasticity and undergoes irreversible deformation, even after the deformation forces are eliminated. If a material deforms irreversibly without increasing stress or load, then this is called ideal plasticity. For example, when a force is applied to an aluminum rod, it changes its shape, but it does not return to its original shape once the force is removed. Plastic deformation or ductility is thus a permanent deformation or change in the...
3.1K
Plasticizers01:31

Plasticizers

375
Water-reducers, or plasticizers, are chemical admixtures used in concrete to improve strength and workability. These additives reduce the water-cement ratio without compromising workability, lower the cement content while maintaining the same workability, or increase workability to assist concrete placement in inaccessible areas.
Plasticizers function by using surface-active agents to create repulsive electrostatic forces between cement particles. This dispersion enhances the concrete's...
375
Plastic Behavior01:21

Plastic Behavior

580
A material's elastic behavior is characterized by the disappearance of stress once the load is removed, allowing the material to return to its original state. However, when stress surpasses the yield point, yielding commences, marking the onset of plastic deformation or permanent set. This change from elastic to plastic behavior is influenced by the peak stress value and the duration before the load is removed. An intriguing observation occurs when a specimen is loaded, unloaded, and...
580
Plastic Deformations01:14

Plastic Deformations

473
It is essential to understand how structural members behave under plastic deformation when the bending stress exceeds the material's yield strength. This state of deformation permanently alters the shape of the member, in contrast to the linear elastic behavior observed before yielding. The strain at any point in the member is expressed in terms of maximum strain. Notably, the neutral axis, which coincides with the centroid during elastic bending, shifts away from the centroid under plastic...
473
Plastic Deformations01:19

Plastic Deformations

472
Plastic deformation represents a fundamental concept in materials science, which explains the irreversible change in the shape of a material when it experiences stress beyond its elastic capability. This phenomenon is important in structural engineering, especially in designing and analyzing cantilever beams—structures that are securely fixed at one end and bear loads at the opposite end. When these beams are subjected to loads within their elastic range, they will return to their...
472
System of Memory01:23

System of Memory

7.4K
Memory is categorized into three major systems: sensory memory, short-term memory (STM), and long-term memory (LTM). These systems differ in their capacity and the duration for which they can hold information. Sensory memory captures raw sensory input from the environment, holding it for just a few seconds or less. For example, on hearing a brief, loud sound, like a car horn honking, the sound seems to linger in the mind for a moment even after it stops. This is an instance of sensory memory...
7.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Single-nucleus profiling reveals a core disease signature and cell type-specific vulnerabilities in early Rett syndrome.

Science advances·2026
Same author

Astrocytic ACSBG1 depletion improves lipid-cytokine signaling and attenuates α-Synuclein pathology in a Parkinson's disease mouse model.

bioRxiv : the preprint server for biology·2026
Same author

A massively parallel reporter assay of <i>MECP2</i> cis-regulatory elements reveals genetic candidates for male-biased autism.

bioRxiv : the preprint server for biology·2026
Same author

Publisher Correction: Presymptomatic training mitigates functional deficits in a mouse model of Rett syndrome.

Nature·2026
Same author

Transcriptomic data and biomedical literature synergize in finding pharmacologic gene regulators.

bioRxiv : the preprint server for biology·2026
Same author

Modulating alternative splicing of <i>MECP2</i> is a potential therapeutic strategy for Rett syndrome.

Science translational medicine·2026

Related Experiment Video

Updated: Feb 10, 2026

Measuring Neural Mechanisms Underlying Sleep-Dependent Memory Consolidation During Naps in Early Childhood
08:20

Measuring Neural Mechanisms Underlying Sleep-Dependent Memory Consolidation During Naps in Early Childhood

Published on: October 2, 2019

12.6K

Unconstrained Plasticity Disrupts Memory Consolidation in a Mouse Model of Rett Syndrome.

Tianrui Rui Zhang1,2, Guanchun Li1,3,2, Jeffrey C Magee1,3,2

  • 1Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA.

Biorxiv : the Preprint Server for Biology
|February 9, 2026
PubMed
Summary

Rett syndrome (RTT) mice show unstable neural representations and memory deficits due to excessive synaptic plasticity. This disruption in place cell stability impairs long-term memory consolidation in RTT models.

More Related Videos

Author Spotlight: A Battery of Highly Reproducible Behavioral Tests to Validate an Angelman Syndrome Murine Model
11:05

Author Spotlight: A Battery of Highly Reproducible Behavioral Tests to Validate an Angelman Syndrome Murine Model

Published on: October 20, 2023

5.8K
Eye Tracking, Cortisol, and a Sleep vs. Wake Consolidation Delay: Combining Methods to Uncover an Interactive Effect of Sleep and Cortisol on Memory
08:08

Eye Tracking, Cortisol, and a Sleep vs. Wake Consolidation Delay: Combining Methods to Uncover an Interactive Effect of Sleep and Cortisol on Memory

Published on: June 18, 2014

27.6K

Related Experiment Videos

Last Updated: Feb 10, 2026

Measuring Neural Mechanisms Underlying Sleep-Dependent Memory Consolidation During Naps in Early Childhood
08:20

Measuring Neural Mechanisms Underlying Sleep-Dependent Memory Consolidation During Naps in Early Childhood

Published on: October 2, 2019

12.6K
Author Spotlight: A Battery of Highly Reproducible Behavioral Tests to Validate an Angelman Syndrome Murine Model
11:05

Author Spotlight: A Battery of Highly Reproducible Behavioral Tests to Validate an Angelman Syndrome Murine Model

Published on: October 20, 2023

5.8K
Eye Tracking, Cortisol, and a Sleep vs. Wake Consolidation Delay: Combining Methods to Uncover an Interactive Effect of Sleep and Cortisol on Memory
08:08

Eye Tracking, Cortisol, and a Sleep vs. Wake Consolidation Delay: Combining Methods to Uncover an Interactive Effect of Sleep and Cortisol on Memory

Published on: June 18, 2014

27.6K

Area of Science:

  • Neuroscience
  • Cognitive Science
  • Genetics

Background:

  • Memory impairment is a key feature of Rett syndrome (RTT).
  • Long-term memory deficits in RTT animal models are not well understood due to challenges in tracking neural activity over time.

Purpose of the Study:

  • To investigate the neural mechanisms underlying long-term memory deficits in RTT using longitudinal imaging.
  • To identify cellular and circuit-level disruptions in memory formation and consolidation in RTT.

Main Methods:

  • Longitudinal two-photon calcium imaging of hippocampal CA1 neurons in RTT mice and controls during a spatial learning task.
  • Analysis of place cell (PC) activity, stability, and ensemble coding.
  • Investigation of behavioral timescale synaptic plasticity (BTSP) incidence and location.

Main Results:

  • RTT mice exhibited excessive place cell activity and pronounced instability of neural representations across days.
  • Disrupted single-cell stability led to unstable population codes, impairing retention of learned information.
  • RTT mice showed a higher incidence of BTSP, which was aberrantly located and disrupted memory consolidation.

Conclusions:

  • Excessive and ectopic BTSP in RTT mice disrupts place cell stability and degrades long-term memory representations.
  • These findings reveal a cellular and circuit-level mechanism for memory deficits in RTT.
  • The identified principles may apply to other neurological disorders with memory impairments.