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Drug Repurposing for Frozen Shoulder; a Bioinformatics Meta-Analysis.
Yashar Shahbaz1, Taimoor Ali2, Atieh Nouralishahi3
1Orthopedic Research Center, Shahid Kamyab Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
The Archives of Bone and Joint Surgery
|January 9, 2026
Summary
This study explored the genetic basis of frozen shoulder (adhesive capsulitis), identifying adenosine as a potential therapeutic target. Further research is needed to validate adenosine-based treatments for this common condition.
Area of Science:
- Genomics
- Bioinformatics
- Molecular Biology
Background:
- Adhesive capsulitis (AC), or frozen shoulder (FS), involves joint capsule contraction, leading to pain and stiffness.
- Genetic factors are suspected contributors to AC etiology.
- Identifying novel therapeutic targets is crucial for managing FS.
Purpose of the Study:
- To investigate the genomic landscape of adhesive capsulitis using bioinformatics.
- To identify potential therapeutic targets for frozen shoulder.
- To explore the role of genetic factors in AC.
Main Methods:
- Systematic review of Gene Expression Omnibus (GEO) datasets (GSE238052, GSE190023, GSE140731).
- Differential gene expression analysis, Gene Ontology (GO) enrichment, and drug-gene enrichment using i-DEP and dpGSEA.
- Analysis of 58,825 genes across 67 samples.
Main Results:
- Identified 1,036 upregulated and 378 downregulated genes in AC.
- Upregulated pathways include skeletal muscle adaptation and myofibril assembly.
- Adenosine and its derivatives emerged as potential therapeutic targets, with significant influence on the disease.
Conclusions:
- The study reveals the genomic profile of adhesive capsulitis.
- Adenosine-related interventions show promise for treating frozen shoulder.
- Experimental validation of adenosine-based therapies is recommended.
