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Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
Association of inflammatory scoring tools with spirometry indices in COVID-19 patients: a single center cohort study
Mohsen Farrokhpour1, Fahimeh Safarnezhad Tameshkel2, Niloufar Sadat Kalaki3,4
1Department of Internal Medicine, Firoozgar Hospital, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Background And Objectives:
Patients with COVID-19 have spirometry parameters linked to various biological markers, including CRP, NLR, MPV, RDW, and APACHE II score. The objective of this study was to investigate the association of inflammatory scoring tools with spirometry indices in a three-month follow-up of COVID-19 patients.
Materials And Methods:
Spirometry records of 369 COVID-19 cases with complications were analyzed at baseline and three months after discharge. Generalized linear models and logistic regression analysis were performed to compare the variables using SPSS version 25 software.
Results:
The baseline NLR was 3.20 (95% CI: 2.96, 3.43); PCT was 0.26 (95% CI: 0.25, 0.27); and MPV was 7.23 (95% CI: 7.10, 7.35). We found that the effects of NLR, CRP, and APACHE II score on the respiratory indices FEV1 and FEV1/FVC three months after discharge had an inverse relationship. Patients with asthma had significantly lower FEV1 and FEV1/FVC values, and the level of FVC did not have any significant difference between people with asthma and COPD patients.
Conclusion:
CRP, NLR, and APACHE II score are among the main factors that are directly related to respiratory indices and they are considered to be appropriate indicators of prognosis for these conditions in COVID-19 patients.
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