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Updated: Jan 13, 2026

A Bedside, Single Burr Hole Approach to Multimodality Monitoring in Severe Brain Injury

A Bedside, Single Burr Hole Approach to Multimodality Monitoring in Severe Brain Injury

Published on: March 26, 2019

A Multimodal Non-invasive Approach for Intracranial Pressure Assessment: A Single-Center Study.

Dana Klavansky¹, Helaina Lehrer², Aris Desai³

¹Neurocritical Care, Mount Sinai Hospital, New York, USA.

|January 9, 2026

Summary

This summary is machine-generated.

A non-invasive multimodal approach using ocular ultrasound and transcranial Doppler shows promise for detecting elevated intracranial pressure (ICP) in acute brain injury patients when invasive monitoring is not feasible.

Keywords:

acute brain injury multi-modal diagnostics neurology and critical care non-invasive monitoring secondary intracranial hypertension

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Last Updated: Jan 13, 2026

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Intracranial Pressure Monitoring In Nontraumatic Intraventricular Hemorrhage Rodent Model

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Published on: February 8, 2022

Area of Science:

Neuroscience
Critical Care Medicine
Medical Imaging

Background:

Intracranial pressure (ICP) monitoring is crucial for managing acute brain injury.
Invasive ICP monitoring has limitations and contraindications.
A validated non-invasive method for ICP detection is needed.

Purpose of the Study:

To validate a multimodal, non-invasive approach for detecting elevated ICP.
To assess the correlation between non-invasive parameters and invasive ICP measurements.

Main Methods:

Retrospective study including acute brain injury patients with external ventricular drain (EVD) placement.
Utilized ocular ultrasound for optic nerve sheath diameter (ONSD) and optic nerve disk elevation (ONDE).
Employed transcranial Doppler for middle cerebral artery pulsatility index (PI) and assessed pupillary reactivity.

Main Results:

A combination of three or more non-invasive variables (e.g., ONSD > 5 mm, ONDE, MCA PI > 1.2, unreactive pupils) showed high specificity and PPV for ICP ≥ 15 mm Hg.
Achieved an area under the ROC curve of 0.84, indicating good diagnostic performance.
Demonstrated strong correlation and agreement between non-invasive assessments and EVD-measured ICP.

Conclusions:

Non-invasive multimodal assessment is feasible and can be performed at the bedside.
This approach shows good correlation with elevated ICP, offering a valuable alternative when invasive monitoring is not possible.