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![[DPEPhosbcpCu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F59739.jpg&w=3840&q=50)
[DPEPhosbcpCu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst
Published on: May 21, 2019
Three-component tandem benzyl-C(sp3)-H functionalization via thermally generated arynes with phenazine
Yajuan Zhang1, Fuxiang Chai1, Qiong Hu1
1Laboratory of Functional Molecular Solids, Ministry of Education, Anhui Key Laboratory of Molecular-Based Materials, School of Chemistry and Materials Science, Anhui Normal University, Wuhu, Anhui 241000, China. yiminhu@ahnu.edu.cn.
None:
A rare strategy for three-component tandem benzyl-C(sp3)-H functionalization via thermally generated arynes with phenazine without a catalyst was developed for the first time. A series of novel fused N,N'-disubstituted dihydrophenazine derivatives were synthesized with excellent yield and high atomic utilization. Deuterium-labelling studies suggested that the formation of carboanion intermediates has a significant role in the reaction. Our data enrich the field of C(sp3)-H functionalization and promote the development of aryne chemistry.
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