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Updated: May 9, 2026

In Vivo Multimodal Imaging and Analysis of Mouse Laser-Induced Choroidal Neovascularization Model
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Choroidal thickness in active lupus nephritis.

Letícia Maria Kolachinski Raposo Brandão1, Lucas Parente de Andrade2, Débora Cordeiro do Rosário1

  • 1Division of Rheumatology, Faculdade de Medicina, Hospital Das Clínicas, Universidade de São Paulo, São Paulo, Brazil.

Lupus
|January 9, 2026
PubMed
Summary
This summary is machine-generated.

Patients with active lupus nephritis (LN) show reduced choroidal thickness (CT). This finding suggests the choroid is a subclinical target organ in LN, and CT may help monitor disease activity non-invasively.

Keywords:
Active lupus nephritischoroidoptical coherence tomography

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Area of Science:

  • Ophthalmology
  • Nephrology
  • Rheumatology

Background:

  • Lupus choroidopathy is linked to severe systemic lupus erythematosus (SLE) activity and lupus nephritis (LN).
  • The relationship between choroidal thickness (CT) and glomerular vascular involvement or LN activity remains debated.
  • This study investigates CT in active LN patients before treatment.

Purpose of the Study:

  • To assess choroidal thickness (CT) in patients with active lupus nephritis (LN).
  • To compare CT in active LN patients with a healthy control group.
  • To explore CT as a potential indicator of LN activity.

Main Methods:

  • A case-control cross-sectional study involving 28 active LN patients and healthy controls.
  • Patients met 2019 ACR/EULAR criteria for SLE; LN confirmed by kidney biopsy in 20 patients.
  • Choroidal thickness (CT) measured using spectral-domain optical coherence tomography (SD-OCT).

Main Results:

  • LN patients and controls had similar age and sex distribution.
  • LN patients exhibited significantly lower mean central subfoveal CT compared to controls (329 ± 69.9 μm vs 297 ± 41.7 μm, p=0.004).
  • Renal parameters showed median creatinine of 0.80 ± 0.26 mg/dL and protein/creatinine ratio of 1.84 ± 1.70 g/g.

Conclusions:

  • Reduced central subfoveal CT in active LN patients suggests the choroid is a subclinical target organ of systemic inflammation.
  • CT measurement is a promising, non-invasive tool for monitoring LN activity.
  • Further longitudinal studies are needed to confirm CT's utility as a biomarker for LN management.