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Related Concept Videos

The JAK-STAT Signaling Pathway01:20

The JAK-STAT Signaling Pathway

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Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as  SH2...
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Related Experiment Video

Updated: Jan 13, 2026

Visualization of Neutrophil Extracellular Traps in Mesenteric Venules After Mesenteric Ischemia-Reperfusion Injury via Intravital Microscopy
07:05

Visualization of Neutrophil Extracellular Traps in Mesenteric Venules After Mesenteric Ischemia-Reperfusion Injury via Intravital Microscopy

Published on: September 27, 2024

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Resveratrol Suppresses Sepsis-Induced Micro-vascular Hypo-reactivity Through Rac1-MLCK Pathway.

Yang Yang1, Jun-Chao Liu2, Zhen-Kui Liu2

  • 1Institute of Microcirculation & Basic Medical College, Hebei North University, Zhangjiakou, Hebei, China.

The Journal of Surgical Research
|January 9, 2026
PubMed
Summary

Resveratrol (Res) improves vascular reactivity in sepsis by targeting the Rac1-MLCK pathway. This study reveals Resveratrol

Keywords:
Rac1-MLCK pathwayResveratrolSepsisVascular reactivity

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Area of Science:

  • Vascular biology
  • Sepsis research
  • Pharmacology

Background:

  • Sepsis-induced vascular hyporeactivity is a major cause of mortality.
  • Resveratrol (Res) shows anti-inflammatory effects and improves vascular reactivity in sepsis models.
  • The precise mechanism of Res's action on sepsis-induced vascular hyporeactivity remains unclear.

Purpose of the Study:

  • To elucidate the mechanism by which Resveratrol mitigates sepsis-induced vascular hyporeactivity.
  • To investigate the role of the Ras-related C3 botulinum toxin substrate (Rac1) and myosin light-chain kinase (MLCK) pathways in Resveratrol's effects.

Main Methods:

  • Established a rat model of sepsis and treated with Resveratrol.
  • Assessed hemodynamic parameters, intestinal microcirculation, and tissue histopathology.
  • Measured mesenteric micro-artery reactivity, vascular smooth muscle cell function, and protein expression of Rac1 and p-MLCK.

Main Results:

  • Resveratrol improved sepsis-induced vascular hyporeactivity and restored microcirculation.
  • Resveratrol enhanced vascular smooth muscle cell viability and contractility.
  • Resveratrol modulated Rac1 and p-MLCK expression, implicating the Rac1-MLCK pathway.

Conclusions:

  • Resveratrol suppresses sepsis-induced microvascular hyporeactivity via the Rac1-MLCK pathway.
  • This finding offers a potential therapeutic strategy for vascular dysfunction in sepsis.