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Framework for cancer evolution profiling and interception in colorectal cancer: ASCEND-CRC program.

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Area of Science:

  • Oncology
  • Translational Medicine
  • Cancer Biology

Background:

  • Cancer evolution is dynamic, but treatments are often static, leading to resistance.
  • Limited tumor sampling hinders the understanding of adaptive states preceding resistance.
  • The ADAPT program by ARPA-H aims to align cancer therapies with real-time tumor evolution.

Purpose of the Study:

  • To uncover early adaptive mechanisms in metastatic colorectal cancer (CRC).
  • To identify dynamic biomarkers for guiding therapeutic decision-making.
  • To establish a scalable platform for intercepting cancer resistance.

Main Methods:

  • The ASCEND-CRC trial integrates multimodal profiling.
  • Longitudinal tracking of tumor evolution is employed.
  • Focus on dynamic biomarkers beyond single pre-treatment markers.

Main Results:

  • Early adaptive mechanisms preceding resistance are being investigated.
  • A set of dynamic biomarkers to inform treatment decisions is being defined.
  • The study is establishing a framework for real-time therapeutic adjustments.

Conclusions:

  • The ASCEND-CRC trial represents a paradigm shift in precision oncology.
  • This initiative aims to transform cancer care by intercepting resistance.
  • Longitudinal, multimodal profiling is key to personalized cancer therapy.