Related Experiment Video For alternative start-codon selection
Updated: Jan 13, 2026

Inducing Apical Periodontitis in Mice
Published on: August 6, 2019
Where you start could determine where you end up
Cecilia A Leber1, Hani S Zaher1
1Department of Biology, Washington University in St Louis, St Louis, MO 63130, USA.
Abstract:
A significant subset of the eukaryotic proteome must localize to multiple cellular compartments, necessitating the emergence of mechanisms to produce protein isoforms with distinct targeting sequences. Ly et al. reveal that alternative start-codon selection during translation initiation is a pervasive mechanism for dual localization of proteins by generating N-terminal isoforms.
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