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Updated: Jan 13, 2026

Plasmodium falciparum Gametocyte Culture and Mosquito Infection Through Artificial Membrane Feeding
Published on: July 3, 2020
MAP-X unveils the shapeshifting interactome of Plasmodium falciparum
1Key Laboratory of Livestock Infectious Diseases, Ministry of Education, College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, 120 Dongling Road, Shenyang 110866, China; Research Unit for Pathogenic Mechanisms of Zoonotic Parasites, Chinese Academy of Medical Sciences, 120 Dongling Road, Shenyang 110866, China.
Abstract:
Pazicky et al. introduced a thermal profiling method, meltome-assisted profiling of protein complexes (MAP-X), combined with machine learning, to map protein complex dynamics in intact Plasmodium falciparum, a deadly malaria parasite. This in situ approach reveals a highly dynamic interactome, identifying novel complexes and 'moonlighting' proteins, shifting our understanding from static lists to temporal networks.
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