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Patient-Perceived Overall Side Effect Bother at and After Cancer Treatment Discontinuation: An Analysis Using
Jessica Roydhouse1, Monique Breslin2, Anne Zola3
1Menzies Institute for Medical Research, University of Tasmania, 15-17 Liverpool Street, Hobart, TAS, 7000, Australia. jessica.roydhouse@utas.edu.au.
Therapeutic Innovation & Regulatory Science
|January 9, 2026
Summary
Persistent side effect bother is common in cancer patients after treatment discontinuation. Capturing this patient-reported outcome data post-treatment is crucial for understanding cancer treatment tolerability.
Area of Science:
- Oncology
- Patient-Reported Outcomes
Background:
- Widespread interest exists in post-treatment patient-reported outcomes (PROs) for cancer care.
- Side effect bother, a key PRO, measures treatment tolerability.
- This study investigates side effect bother at and after cancer treatment discontinuation.
Purpose of the Study:
- To examine side effect bother in patients discontinuing cancer treatment.
- To assess PRO completion rates at and after treatment discontinuation.
- To understand the association between side effect bother and other PROs.
Main Methods:
- Data from three solid tumor trials (renal cell carcinoma, breast cancer) were analyzed.
- Side effect bother was measured using the Functional Assessment of Chronic Illness Therapy (FACIT) GP5 item.
- Symptom and function data were collected using FACIT and EQ-5D-3L, with analyses including descriptive and correlation statistics.
Main Results:
- PRO completion rates at discontinuation were generally high (≥70%), decreasing to 52-78% at follow-up.
- Over 20% of patients reported high side effect bother, alongside similar rates for symptom and functional issues.
- The FACIT GP5 item showed moderate correlations (≥0.2) with most other PRO items.
Conclusions:
- Persistent side effect bother and functional impairments are evident post-treatment discontinuation.
- Collecting PRO data after treatment cessation is vital for a comprehensive understanding of cancer treatment tolerability.
- Improved PRO completion rates can enhance the insights gained from post-treatment data.
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