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Method for Novel Anti-Cancer Drug Development using Tumor Explants of Surgical Specimens

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Circulating Tumor Cells in Glioblastoma.

Robert H Eibl¹, Markus Schneemann²

¹c/o M. Schneemann, Department of Internal Medicine, Hospitals of Schaffhausen, 8208 Schaffhausen, Switzerland.

|January 10, 2026

Summary

This summary is machine-generated.

Glioblastoma circulating tumor cells (CTCs) challenge the non-metastatic view of this brain tumor. Liquid biopsy using CTCs offers new avenues for glioblastoma diagnosis and personalized treatment monitoring.

Keywords:

CTC GBM biomarker circulating tumor cell clinical trials glioblastoma liquid biopsy precision medicine

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Live-Cell Imaging Assays to Study Glioblastoma Brain Tumor Stem Cell Migration and Invasion

Live-Cell Imaging Assays to Study Glioblastoma Brain Tumor Stem Cell Migration and Invasion

Published on: August 29, 2018

Area of Science:

Neuro-oncology
Cancer Biology
Molecular Diagnostics

Background:

Glioblastoma multiforme (GBM) is an aggressive brain tumor with a historically poor prognosis.
GBM was traditionally considered non-metastatic, but recent findings of circulating tumor cells (CTCs) challenge this paradigm.
The detection of CTCs in GBM opens new possibilities for liquid biopsy in neuro-oncology.

Purpose of the Study:

To review the current understanding of glioblastoma CTCs.
To highlight their unique characteristics, detection methods, and challenges.
To explore their potential in personalized glioblastoma management.

Main Methods:

Review of current literature on glioblastoma CTCs.
Analysis of detection technologies and their limitations.
Comparison of GBM CTCs with those from extracranial cancers.

Main Results:

GBM CTCs possess unique properties and face challenges like rarity and the blood-brain barrier.
Specialized enrichment techniques are necessary for their detection.
CTC analysis provides insights into tumor heterogeneity, treatment response, and minimal residual disease.

Conclusions:

Circulating tumor cells in glioblastoma offer valuable information for dynamic tumor surveillance.
Emerging clinical studies show promise for early relapse detection and therapy monitoring.
Integrating CTC analysis with other liquid biopsy methods can transform glioblastoma management and improve patient outcomes.