Endothelial Activation and Stress Index (EASIX) Predicts In-Hospital Mortality in Acute Decompensated Heart Failure
Bülent Özlek1, Veysel Ozan Tanık2, Alperen Taş3
1Department of Cardiology, School of Medicine, Mulla Sıtkı Koçman University, Muğla 48000, Turkey.
Diagnostics (Basel, Switzerland)
|January 10, 2026
Summary
The Endothelial Activation and Stress Index (EASIX) effectively predicts in-hospital mortality in acute decompensated heart failure with reduced ejection fraction (ADHF-rEF). This accessible biomarker offers valuable prognostic information for early risk stratification.
Area of Science:
- Cardiology
- Biomarkers
- Prognostics
Background:
- Early risk stratification for acute decompensated heart failure with reduced ejection fraction (ADHF-rEF) is clinically challenging.
- Endothelial dysfunction, reflected by the Endothelial Activation and Stress Index (EASIX), contributes to ADHF-rEF deterioration.
- The EASIX composite includes lactate dehydrogenase, creatinine, and platelet count.
Purpose of the Study:
- To evaluate the prognostic utility of admission-based EASIX for predicting in-hospital mortality in ADHF-rEF patients.
- To assess if EASIX provides incremental prognostic value beyond established predictors.
Main Methods:
- Retrospective analysis of 850 consecutive ADHF-rEF patients.
- EASIX calculated from first-day laboratory values.
- Logistic regression, ROC analysis, and survival methods used to assess mortality association.
Main Results:
- In-hospital mortality was 12.4%.
- Higher EASIX values significantly predicted mortality (adjusted OR 1.273, p < 0.001).
- EASIX demonstrated moderate discrimination (AUC 0.751) and a clear risk gradient, improving existing prediction models.
Conclusions:
- Admission EASIX is an independent predictor of in-hospital mortality in ADHF-rEF.
- EASIX offers complementary prognostic information, enhancing conventional risk stratification models.
- This study highlights EASIX's potential as an accessible endothelial stress biomarker for early risk assessment.
Keywords:
EASIX scoreacute decompensated heart failureendothelial dysfunctionin-hospital mortalityrisk stratificationMore Related Videos
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