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Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation
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Targeting the Glutaminolysis Pathway in Glaucoma-Associated Fibrosis
Áine Kelly1,2, Mustapha Irnaten1,2, Colm O'Brien1,2
1Department of Ophthalmology, Mater Misericordiae University Hospital, D07 R2WY Dublin, Ireland.
International Journal of Molecular Sciences
|January 10, 2026
Summary
Glaucoma involves fibrosis and metabolic changes. Targeting glutaminolysis, an energy pathway, may offer new glaucoma treatments by addressing fibrosis and cell growth.
Area of Science:
- Ophthalmology
- Cell Biology
- Metabolic Pathways
Background:
- Glaucoma is a leading cause of irreversible blindness characterized by optic neuropathy.
- Key pathological features include fibrosis in the trabecular meshwork, Schlemm's Canal, and lamina cribrosa.
- Fibrosis involves extracellular matrix (ECM) remodeling and metabolic reprogramming.
Purpose of the Study:
- To review the role of fibrosis and glutaminolysis in glaucoma.
- To explore glutaminolysis as a potential therapeutic target for glaucoma.
Main Methods:
- Literature review of fibrosis, metabolic reprogramming, and glutaminolysis in cancer and fibrotic diseases.
- Analysis of existing therapies targeting these pathways.
Main Results:
- Fibrosis and metabolic reprogramming are central to glaucoma pathogenesis.
- Glutaminolysis, an alternative energy pathway, is implicated in cancer and systemic fibrotic diseases, facilitating ECM remodeling and proliferation.
- Evidence suggests a predilection for glutaminolysis in fibrotic processes.
Conclusions:
- Glutaminolysis plays a significant role in the metabolic reprogramming associated with fibrosis.
- Targeting glutaminolysis presents a promising avenue for future glaucoma therapies.
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