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Updated: Jan 13, 2026

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How Early-Life Programming During Embryogenesis Imprints Cellular Memory.

Norermi Firzana Alfian1, Kei Uechi1, Yoshiya Morishita1

  • 1Department of Integrated Applied Life Science, Integrated Graduate School of Medicine, Engineering, and Agricultural Sciences, University of Yamanashi, Kofu 400-0016, Japan.

International Journal of Molecular Sciences
|January 10, 2026
PubMed
Summary
This summary is machine-generated.

Cellular memory, established by epigenetic modifications during early development, influences adult health and disease. Understanding these early-life exposures is key to preventing long-term metabolic disorders.

Keywords:
DOHaDcellular memoryembryogenesisepigenetic inheritance

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Area of Science:

  • Epigenetics and Developmental Biology

Background:

  • Cellular memory, or epigenetic memory, allows cells to retain information beyond DNA sequence.
  • Epigenetic mechanisms maintain specialized cell characteristics across divisions, crucial for tissue identity and differentiation.

Purpose of the Study:

  • To review advances in epigenetic pathways mediating cellular memory.
  • To highlight vulnerable windows in early embryogenesis and their link to adult health.
  • To identify gaps for developing interventions safeguarding future generations.

Main Methods:

  • Review of recent scientific literature on epigenetic mechanisms.
  • Synthesis of data on early-life exposures and their long-term health impacts.
  • Analysis of epigenetic modifications like DNA methylation, histone modifications, and non-coding RNAs.

Main Results:

  • Early embryonic exposures, including assisted reproductive technologies and nutritional stress, can establish epigenetic memory.
  • This memory links early-life events to adult phenotypes, particularly metabolic disorders.
  • Epigenetic modifications are crucial for transmitting cellular memory across cell divisions and, in some cases, across generations.

Conclusions:

  • Epigenetic memory plays a critical role in the Developmental Origins of Health and Disease (DOHaD).
  • Critical preimplantation windows exist where interventions can mitigate long-term health risks.
  • Further research is needed to develop mammalian interventions that leverage epigenetic memory to safeguard health across generations.