Research on rhubarb's natural components and their potential for treating chronic kidney disease

Renal fibrosis, a major pathological alteration in chronic kidney disease, is characterized by several changes, such as excessive extracellular matrix deposition, renal tubular cells' epithelial-mesenchymal transition, and fibroblast proliferation and activation. It has been demonstrated that rhubarb, a possible natural substance, may be used as a regular or supplemental treatment for chronic renal disease. Through a variety of pharmacological actions, including the anti-inflammatory and antioxidant qualities of natural ingredients, it may target renal fibrosis and produce its effects. This article offers fresh concepts for the creation of novel anti-renal fibrosis medications by succinctly introducing the pathological process of renal fibrosis and methodically summarizing the most recent studies on the use of rhubarb's natural constituents to treat renal fibrosis.