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Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer
Published on: February 12, 2017
DIAMOND in nasopharyngeal carcinoma: Time to drop cisplatin?
Emma R Y Zhang1, Ya Juan Zhou2, Melvin L K Chua3
1Division of Medical Sciences, National Cancer Centre Singapore, 30 Hospital Boulevard, Singapore 168583, Singapore; Department of Mathematics, University of California, Los Angeles, 520 Portola Plaza, MS 6363, Los Angeles, CA 90095-1555, USA.
None:
The phase 3 DIAMOND trial conducted in patients with locoregionally advanced nasopharyngeal carcinoma (LA-NPC) reported comparable 3-year failure-free survival rates between a cisplatin-containing versus a cisplatin-free regimen with radiotherapy, in the backbone of induction, concurrent, and adjuvant anti-programmed death-1 (anti-PD-1) therapy.1 Reduced cisplatin-related emesis also improved quality of life. DIAMOND challenges the conventional dogma of concurrent cisplatin-radiotherapy in the treatment of LA-NPC.
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