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Related Experiment Video

Updated: Jan 13, 2026

Melt Electrospinning Writing of Three-dimensional Poly(ε-caprolactone) Scaffolds with Controllable Morphologies for Tissue Engineering Applications

Melt Electrospinning Writing of Three-dimensional Poly(ε-caprolactone) Scaffolds with Controllable Morphologies for Tissue Engineering Applications

Published on: December 23, 2017

Rational Design and Functionalization of Melt Electrowritten 4D Scaffolds for Biomedical Applications.

Yanping Zhang¹, Fengqiang Zhao², Aike Qiao³

¹Department of Biomedical Engineering, College of Chemical and Life Science, Beijing University of Technology, Beijing, 100124, People's Republic of China. yanping@bjut.edu.cn.

Nano-Micro Letters

|January 11, 2026

Summary

This summary is machine-generated.

Melt electrowriting (MEW) enables 4D printing of dynamic, shape-changing scaffolds. These advanced biomimetic structures offer precise control for biomedical applications like tissue engineering and drug delivery.

Keywords:

4D printing Biomedical applications Dynamic biomimetic scaffolds Melt electrowriting (MEW)

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Last Updated: Jan 13, 2026

Melt Electrospinning Writing of Three-dimensional Poly(ε-caprolactone) Scaffolds with Controllable Morphologies for Tissue Engineering Applications

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Area of Science:

Biomaterials Science
Additive Manufacturing
4D Printing

Background:

Melt electrowriting (MEW) fabricates micro-/nanoscale polymeric fibers for 3D biomimetic scaffolds.
Incorporating stimuli-responsive polymers enables 4D printing, creating scaffolds with dynamic shape transformations.

Purpose of the Study:

To systematically review MEW-based 4D printing principles for biomimetic scaffolds.
To elucidate material considerations, actuation methods, and design strategies for dynamic 4D scaffolds.

Main Methods:

Overview of MEW process for 4D printing.
Analysis of stimuli-responsive materials and external stimuli for MEW compatibility.
Discussion of design strategies for shape programming and morphing.

Main Results:

MEW-based 4D printing allows rational fabrication of versatile biomimetic scaffolds.
Dynamic 4D scaffolds demonstrate potential in tissue engineering, biomedical implants, and drug delivery.
Progress in material innovation, fabrication optimization, and actuation control is highlighted.

Conclusions:

MEW-based 4D printing offers a powerful platform for creating multifunctional, dynamic biomimetic scaffolds.
Further research in material science and fabrication is crucial for optimizing MEW 4D printing applications.
This review provides insights for designing advanced dynamic scaffolds for biomedical use.