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Related Concept Videos

Ultrasonography01:17

Ultrasonography

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Ultrasonography is an imaging technique that uses high-frequency sound waves to visualize the body's internal structures. It is a non-invasive and safe procedure that does not involve the use of ionizing radiation, making it widely used in various medical fields. Ultrasonography is used to study heart function, blood flow in the neck or extremities, certain conditions such as gallbladder disease, and fetal growth and development.
During an ultrasonography procedure, a handheld device called...
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Imaging Studies II: Ultrasonography01:24

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IntroductionUltrasonography, or renal ultrasound, is a noninvasive medical imaging technique that uses high-frequency sound waves to visualize the kidneys, ureters, bladder, and surrounding tissues.Indications for Urinary System UltrasonographyUrinary system ultrasonography is indicated in various clinical scenarios, such as:Kidney Stones (Urolithiasis): To detect and monitor the size and presence of kidney or urinary tract stones.Hydronephrosis: To assess the dilation of the renal pelvis and...
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Ultrasound II: Endoscopic Ultrasound and FibroScan01:25

Ultrasound II: Endoscopic Ultrasound and FibroScan

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Endoscopic Ultrasound (EUS) and FibroScan are valuable diagnostic tools in gastroenterology and hepatology, each with specific applications and techniques.
Endoscopic Ultrasound (EUS):
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Related Experiment Video

Updated: Jan 13, 2026

Blood Flow Imaging with Ultrafast Doppler
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Quantitative Multifrequency Ultrasound Imaging Using Narrowband Pulsing for Tissue Characterization.

Joshua Hanson, Chaodong Wu, Kenneth Hoyt

    Investigative Radiology
    |January 12, 2026
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    Summary
    This summary is machine-generated.

    Multifrequency ultrasound (MFUS) accurately measures liver steatosis in mice by quantifying ultrasound attenuation and scatterer size. This novel technique shows promise for diagnosing metabolic dysfunction-associated steatotic liver disease (MASLD).

    Keywords:
    attenuationliver steatosismultifrequency ultrasoundrelative scatterer sizetissue characterizationultrasound

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    A Novel Application of Musculoskeletal Ultrasound Imaging
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    Area of Science:

    • Medical Imaging
    • Biophysics
    • Quantitative Ultrasound

    Background:

    • Metabolic dysfunction-associated steatotic liver disease (MASLD) is a growing health concern.
    • Accurate, non-invasive diagnostic tools for MASLD are needed.
    • Multifrequency ultrasound (MFUS) is an emerging quantitative imaging technique.

    Purpose of the Study:

    • To implement a MFUS acquisition sequence.
    • To validate MFUS quantitative measurements using an animal model of MASLD.
    • To assess MFUS for liver tissue characterization.

    Main Methods:

    • Acquired radiofrequency (RF) data using MFUS with 24 frequency-shifted pulses.
    • Calculated MFUS gradient, ultrasound attenuation coefficient, and relative scatterer size (RSS).
    • Validated in vitro with tissue-mimicking phantoms and in vivo with mice fed a standard or MCD diet.

    Main Results:

    • In vitro MFUS accurately estimated attenuation coefficients.
    • MFUS demonstrated sensitivity to scatterer size and improved contrast-to-noise ratio (CNR).
    • In vivo, MCD-fed mice showed increased attenuation and decreased RSS, consistent with MASLD.

    Conclusions:

    • MFUS imaging is sensitive to changes in attenuation and scatterer size.
    • Preliminary preclinical results validate MFUS for liver tissue characterization in MASLD.
    • MFUS is an innovative technique with potential for further optimization and application.