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Related Concept Videos

Tooth Anatomy01:21

Tooth Anatomy

2.0K
The human tooth enables us to eat a variety of foods, speak clearly, and even aid in shaping our faces. Teeth are composed of various elements that work together. Here's a detailed look at the anatomy of a human tooth.
The Crown, Neck, and Root
The visible part of the tooth is referred to as the crown. It's covered by enamel, the hardest substance in the human body. The crown is uniquely shaped for each type of tooth, allowing for different functions such as cutting, tearing, or...
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Related Experiment Video

Updated: Jan 13, 2026

Development of a Direct Pulp-capping Model for the Evaluation of Pulpal Wound Healing and Reparative Dentin Formation in Mice
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Dentin Autograft as a Pulp Capping Material: A Systematic Review.

Wasifoddin A Chaudhari1, Sameer K Jadhav2, Manu Bansal1

  • 1Department of Conservative Dentistry and Endodontics, Jaipur Dental College, Jaipur, Rajasthan, India.

Journal of Pharmacy & Bioallied Sciences
|January 12, 2026
PubMed
Summary
This summary is machine-generated.

New dentin-derived materials show promise for vital pulp therapy, promoting reparative dentinogenesis and pulp vitality. These bioactive grafts offer a regenerative alternative to traditional pulp capping agents.

Keywords:
Demineralized dentindentin autograftdirect pulp cappingtreated dentin matrixvital pulp therapy

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Area of Science:

  • Biomaterials Science
  • Regenerative Dentistry
  • Dental Pulp Biology

Background:

  • Vital pulp therapy aims to preserve pulp vitality and stimulate dentin repair after exposure.
  • Conventional agents like calcium hydroxide and mineral trioxide aggregate are standard, but novel bioactive materials are emerging.
  • Interest is growing in autograft and xenograft dentin-derived materials for enhanced regenerative potential.

Purpose of the Study:

  • To review and assess the regenerative performance of various dentin-derived materials in vital pulp therapy.
  • To evaluate outcomes such as pulp vitality, reparative dentin formation, and inflammatory response.
  • To compare the efficacy of demineralized bone matrix, dentin matrix hydrogel, xenogeneic dentin paste, and autologous dentin matrix.

Main Methods:

  • Systematic review of five experimental studies in rat, canine, swine, and human models.
  • Assessment of demineralized bone matrix, treated dentin matrix hydrogel, xenogeneic demineralized dentin paste, and autologous demineralized dentin matrix.
  • Evaluation of inflammatory response, pulp tissue organization, dentin bridge formation, odontogenic markers, biodegradation, and regenerated dentin quality.

Main Results:

  • All evaluated dentin-derived materials preserved pulp vitality and induced reparative dentin formation.
  • Demineralized bone matrix showed reduced inflammation compared to calcium hydroxide.
  • Treated dentin matrix hydrogel and xenogeneic dentin paste formed complete, organized dentin bridges.
  • Autologous dentin matrix yielded high-quality reparative dentin, comparable or superior to controls.
  • Dentin-derived materials exhibited favorable biocompatibility and minimal inflammation.

Conclusions:

  • Dentin-derived materials demonstrate significant potential as regenerative alternatives for pulp capping.
  • These bioactive grafts promote organized dentinogenesis and maintain pulp vitality effectively.
  • Further standardized clinical trials are necessary to confirm long-term efficacy and clinical applicability.