Hokuriku-plus Heart Failure Registry Study　- Rationale and Study Design.

Area of Science:

• Cardiology
• Public Health
• Biomarkers

Background:

• Heart failure (HF) presents a growing public health challenge in Japan, exacerbated by an aging demographic.
• The Hokuriku-plus Heart Failure Registry (HpHFR) protocol is detailed herein.
• The registry aims to create a comprehensive clinical and digital database for identifying novel prognostic indicators in HF patients.

Purpose of the Study:

• To establish a prospective, multicenter observational cohort study in Japan.
• To enroll patients with acute or chronic heart failure (HF).
• To assess novel prognostic indicators for HF using integrated clinical, digital, and genomic data.

Main Methods:

• Prospective, multicenter observational cohort study involving 5 Japanese centers.
• Baseline assessments included clinical, laboratory, and biometric data, with digital phonocardiography and wearable device integration.
• Follow-up assessments scheduled at 4, 12, 26, and 52 weeks, with primary outcomes of all-cause death, HF hospitalization, and HF worsening.

Main Results:

• The study enrolled patients with acute or chronic heart failure (HF).
• Data collection includes clinical, laboratory, biometric, digital phonocardiography, and wearable device information.
• Primary outcomes focus on mortality, hospitalization, and HF exacerbation, with secondary outcomes on clinical parameter changes.

Conclusions:

• The HpHFR protocol outlines the creation of a valuable prospective cohort resource.
• The registry will yield a unique dataset for multifaceted investigations into HF prediction and management.
• Integration of clinical, laboratory, digital biometric, and genomic data aims to improve HF care.