Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pulmonary Hypertension: Classification and Pathogenesis01:30

Pulmonary Hypertension: Classification and Pathogenesis

562
Pulmonary hypertension (PH) is a severe health condition in which the mean pulmonary arterial pressure increases to 25 mmHg or more, even when the body is at rest. This high pressure in the blood vessels that transport blood from the heart to the lungs can cause various symptoms, including shortness of breath, can lead to right heart failure, and significantly affect the overall quality of life.
There are various classifications for PH, each relating to different underlying causes and also...
562
Psychoneuroimmunology: Cardiovascular Disease01:27

Psychoneuroimmunology: Cardiovascular Disease

382
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
382
COPD: Pathogenesis and Clinical Features01:20

COPD: Pathogenesis and Clinical Features

1.7K
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
1.7K
Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.01:25

Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.

3.5K
Understanding the variety of primary symptoms and systemic complications that characterize chronic obstructive pulmonary disease (COPD) is crucial for healthcare professionals.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
3.5K
Odds Ratio01:09

Odds Ratio

1.6K
The odds ratio (OR) is a statistical measure used extensively in epidemiology and research to quantify the strength of association between exposure and outcome across different groups. Unlike relative risk, which compares the probabilities of an event occurring, the odds ratio compares the odds of an event occurring in the exposed group to the odds of it occurring in the unexposed group. The odds, in this context, are calculated as the probability of the event happening divided by the...
1.6K
Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

4.2K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
4.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Vascular and Metabolic Face of Alopecia Areata: Insights from an Indian Cohort.

Indian dermatology online journal·2026
Same author

Prolactin as a Biomarker of Disease Activity in Autoimmune Bullous Disorders-A Case-Control Study.

Indian dermatology online journal·2026
Same author

Cutaneous Larva Migrans.

Journal of cutaneous medicine and surgery·2026
Same author

Mapping the nexus: tracing blood pressure changes in patients with psoriasis.

Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace·2026
Same author

Beyond hair loss: Exploring the link between alopecia areata and non-alcoholic fatty liver disease.

Tropical doctor·2026
Same author

Pediatric Psoriasis: A Peek into the Comorbidity Profile.

Indian journal of dermatology·2026

Related Experiment Video

Updated: Jan 14, 2026

Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients
02:28

Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients

Published on: March 1, 2024

759

Do Nails Tell a Pulmonary Tale? A Cross-Sectional Study on Psoriasis and Pulmonary Hypertension Risk.

Sharang Gupta1, Dimple Chopra2

  • 1Department of Dermatology, Civil Hospital, Nabha, Patiala, Punjab, India.

Journal of Cutaneous Medicine and Surgery
|January 12, 2026
PubMed
Summary

Nail psoriasis severity, measured by the Nail Psoriasis Severity Index (NAPSI), independently predicts pulmonary arterial hypertension (PAH) in psoriasis patients. Higher NAPSI scores correlate with increased PAH risk, suggesting nail assessment as a tool for identifying patients needing further cardiac evaluation.

Keywords:
NAPSIechocardiographynail psoriasispsoriasispulmonary arterial hypertensionsystemic inflammation

More Related Videos

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
10:21

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma

Published on: September 20, 2024

715
The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
11:39

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

39.4K

Related Experiment Videos

Last Updated: Jan 14, 2026

Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients
02:28

Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients

Published on: March 1, 2024

759
Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
10:21

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma

Published on: September 20, 2024

715
The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
11:39

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

39.4K

Area of Science:

  • Dermatology and Cardiology
  • Systemic Inflammatory Diseases
  • Cardiopulmonary Comorbidities

Background:

  • Psoriasis is a systemic inflammatory disease linked to cardiopulmonary issues.
  • Nail psoriasis, assessed by NAPSI, indicates severe disease.
  • Pulmonary arterial hypertension (PAH) is more common in psoriasis, but its link to nail psoriasis severity is unclear.

Purpose of the Study:

  • To examine the relationship between NAPSI scores and the presence/severity of PAH in psoriasis patients.
  • To determine if nail psoriasis severity is an independent predictor of PAH.

Main Methods:

  • A prospective, cross-sectional study of 100 psoriasis patients.
  • Dermatological evaluation (PASI, NAPSI), echocardiography (PASP measurement), and inflammatory marker assessment (CRP, IL-17, TNF-α).
  • PAH defined as PASP > 35 mmHg; statistical analyses included correlation and regression.

Main Results:

  • PAH found in 29% of patients, more prevalent in those with nail psoriasis (40% vs 18%).
  • Higher NAPSI scores correlated with higher PASP (r=0.44, P<.001).
  • NAPSI, PASI, and CRP were independent predictors of PAH; nail matrix involvement showed stronger association.

Conclusions:

  • NAPSI, PASI scores, and CRP levels predict PAH in psoriasis patients.
  • Nail psoriasis severity assessment can identify patients at higher risk for pulmonary vascular complications.
  • Further cardiological evaluation is recommended for high-risk psoriasis patients.