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Early COVID-19 and Severity of Subsequent Omicron Infection in Ontario Canada
Caroline Kassee1, Altynay Shigayeva1, Christopher Kandel2,3
1Department of Microbiology, Sinai Health, Toronto, Canada.
Abstract:
We evaluated whether having early COVID-19 reduced the severity of subsequent Omicron infection, assessing activities of daily living (ADL), healthcare utilization and illness duration. Comparisons were made between persons with (1) early COVID-19-compatible illness with a negative test, (2) early lab-confirmed SARS-CoV-2 14-26 months and (3) early lab-confirmed SAR-CoV-2 > 26 months before Omicron infection. Among 261 patients with laboratory-confirmed Omicron, 177 (68%) had COVID-19 in 2020, a median of 793 days (IQR, 659-902) prior to Omicron infection. Compared to no early COVID-19, COVID-19 14-26 months, but not > 26 months, before was associated with reduced impact on ADL during first Omicron infection (OR 0.52, 95% CI 0.29-0.93).
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