Lifespan-Extending Endogenous Metabolites.

Area of Science:

• Gerontology and Metabolic Regulation
• Molecular Biology and Epigenetics

Background:

• Aging is a complex process influenced by genetics, environment, and metabolism.
• Metabolic dysfunction and impaired nutrient sensing are central to aging.
• Interventions like caloric restriction and reduced insulin/IGF-1 signaling extend lifespan.

Purpose of the Study:

• To review the role of endogenous metabolites in aging and lifespan extension.
• To discuss the mechanisms by which metabolites influence aging pathways.
• To explore the translational potential of metabolite-based interventions for healthspan.

Main Methods:

• Literature review of studies on aging, metabolism, and longevity.
• Analysis of evidence from diverse model organisms.
• Synthesis of findings on metabolite function and mechanisms.

Main Results:

• Endogenous metabolites act as crucial mediators between nutrient status and cellular processes.
• Key metabolites have demonstrated lifespan-extending effects across various species.
• Metabolites integrate into networks that modulate multiple aging-related pathways.

Conclusions:

• Targeting metabolic networks with endogenous metabolites is a viable strategy to delay aging.
• Metabolite-based interventions hold translational promise for extending healthspan.
• Challenges remain in optimizing dosing, understanding context-specific effects, and proving human efficacy.