Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Replication in Eukaryotes01:29

Replication in Eukaryotes

17.0K
In eukaryotic cells, DNA replication is highly conserved and tightly regulated. Multiple linear chromosomes must be duplicated with high fidelity before cell division, so there are many proteins that fulfill specialized roles in the replication process. Replication occurs in three phases: initiation, elongation, and termination, and ends with two complete sets of chromosomes in the nucleus.
Many Proteins Orchestrate Replication at the Origin
Eukaryotic replication follows many of the same...
17.0K
Replication in Eukaryotes02:31

Replication in Eukaryotes

202.9K
Overview
202.9K
Mitochondria01:37

Mitochondria

19.5K
Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
19.5K
What is Metabolism?00:52

What is Metabolism?

131.0K
Overview
131.0K
Drug Metabolism: Phase II Reactions01:14

Drug Metabolism: Phase II Reactions

4.8K
Phase II reactions are essential for the detoxification and elimination of drugs from the body. These reactions involve the conjugation of parent drugs or their phase I metabolites with endogenous molecules, resulting in more hydrophilic drug conjugates. The primary conjugation reactions in this phase are sulfation and glucuronidation. Both sulfation and glucuronidation typically produce biologically inactive metabolites. However, in some cases involving prodrugs, active metabolites may be...
4.8K
Regulation of Metabolism01:19

Regulation of Metabolism

11.4K
Cellular needs and conditions vary from cell to cell and change within individual cells over time. For example, the required enzymes and energetic demands of stomach cells are different from those of fat storage cells, skin cells, blood cells, and nerve cells. Furthermore, a digestive cell works much harder to process and break down nutrients during the time that closely follows a meal compared with many hours after a meal. As these cellular demands and conditions vary, so do the amounts and...
11.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

On-demand formation of ultrathin liquid metal hydrogel tattoos for conformal and low-impedance bioelectronics.

Science advances·2026
Same author

Skin aging: mechanisms, evaluation, and rejuvenation.

The EMBO journal·2026
Same author

A generative AI framework unifies human multi-omics to model aging, metabolic health, and intervention response.

Cell metabolism·2026
Same author

Rapid rescue of despair behaviors by sonogenetic neuromodulation of the mPFC-DRN pathway.

Molecular psychiatry·2026
Same author

[Molecular mechanisms and clinical applications of anti-angiogenic therapy in precision treatment of breast cancer].

Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences·2026
Same author

Integrative multi-omic analysis identified <i>ERBB2</i> mutations and senescence-driven immune suppression as dual therapeutic targets in LAR triple-negative breast cancer.

Cancer biology & medicine·2026
Same journal

A Non-Canonical Role for Hepatocyte MLKL in Promoting Mitochondrial Dysfunction and Senescence in the Aging Liver.

Aging cell·2026
Same journal

EGR1 Mediates Ursodeoxycholic Acid-Promoted Mitophagy to Prevent Postovulatory Aging of Porcine Oocytes.

Aging cell·2026
Same journal

Interplay of the ENS and Microbiota With Murine Gut Epithelium-Derived Organoids in Aging.

Aging cell·2026
Same journal

Age-Associated Senescence of Decidual Macrophages: A Key Mediator of Adverse Pregnancy Outcomes in Advanced Maternal Age.

Aging cell·2026
Same journal

Correction to "Telomerase Knockout in Myeloid Cells Predisposes Mice to Foam Cell Formation, Dyslipidemia, Lung Fibrosis, and Cardiac Dysfunction".

Aging cell·2026
Same journal

Bidirectional Relationship and Shared Mechanisms Between Sarcopenia and Osteoporosis: An Observational Study Integrating Genomic, Proteomic, and Metabolomic Data.

Aging cell·2026
See all related articles

Related Experiment Video

Updated: Jan 14, 2026

Lipid Supplementation for Longevity and Gene Transcriptional Analysis in Caenorhabditis elegans
07:25

Lipid Supplementation for Longevity and Gene Transcriptional Analysis in Caenorhabditis elegans

Published on: December 9, 2022

2.0K

Lifespan-Extending Endogenous Metabolites.

Yizhou Jiang1,2, Jing-Dong J Han3,4

  • 1Key Laboratory of Reproductive Health Diseases Research and Translation of Ministry of Education, International Center for Aging and Cancer, Hainan Medical University, Haikou, China.

Aging Cell
|January 13, 2026
PubMed
Summary
This summary is machine-generated.

Key endogenous metabolites regulate aging and extend lifespan by influencing nutrient sensing and epigenetic pathways. Targeting these metabolic networks offers a promising strategy for delaying aging and improving healthspan.

Keywords:
aginganti‐aginglifespanmetabolismmetabolites

More Related Videos

Measuring Caenorhabditis elegans Life Span in 96 Well Microtiter Plates
12:23

Measuring Caenorhabditis elegans Life Span in 96 Well Microtiter Plates

Published on: March 18, 2011

37.8K
A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae
10:39

A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae

Published on: September 17, 2020

6.7K

Related Experiment Videos

Last Updated: Jan 14, 2026

Lipid Supplementation for Longevity and Gene Transcriptional Analysis in Caenorhabditis elegans
07:25

Lipid Supplementation for Longevity and Gene Transcriptional Analysis in Caenorhabditis elegans

Published on: December 9, 2022

2.0K
Measuring Caenorhabditis elegans Life Span in 96 Well Microtiter Plates
12:23

Measuring Caenorhabditis elegans Life Span in 96 Well Microtiter Plates

Published on: March 18, 2011

37.8K
A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae
10:39

A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae

Published on: September 17, 2020

6.7K

Area of Science:

  • Gerontology and Metabolic Regulation
  • Molecular Biology and Epigenetics

Background:

  • Aging is a complex process influenced by genetics, environment, and metabolism.
  • Metabolic dysfunction and impaired nutrient sensing are central to aging.
  • Interventions like caloric restriction and reduced insulin/IGF-1 signaling extend lifespan.

Purpose of the Study:

  • To review the role of endogenous metabolites in aging and lifespan extension.
  • To discuss the mechanisms by which metabolites influence aging pathways.
  • To explore the translational potential of metabolite-based interventions for healthspan.

Main Methods:

  • Literature review of studies on aging, metabolism, and longevity.
  • Analysis of evidence from diverse model organisms.
  • Synthesis of findings on metabolite function and mechanisms.

Main Results:

  • Endogenous metabolites act as crucial mediators between nutrient status and cellular processes.
  • Key metabolites have demonstrated lifespan-extending effects across various species.
  • Metabolites integrate into networks that modulate multiple aging-related pathways.

Conclusions:

  • Targeting metabolic networks with endogenous metabolites is a viable strategy to delay aging.
  • Metabolite-based interventions hold translational promise for extending healthspan.
  • Challenges remain in optimizing dosing, understanding context-specific effects, and proving human efficacy.