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Related Concept Videos

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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
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Updated: Jan 14, 2026

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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Biomarkers.

Wiktoria Piaszczynska1, Miray Budak2, Bryan Rowe3

  • 1Center for Molecular & Behavioral Neuroscience, Rutgers University-Newark, Newark, NJ, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|January 13, 2026
PubMed
Summary
This summary is machine-generated.

Autosomal dominant Alzheimer's disease (ADAD) mutations reduce medial temporal lobe (MTL) network flexibility, indicating early functional changes. Larger right entorhinal cortex volume correlated with better cognitive function in ADAD carriers.

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Area of Science:

  • Neuroscience
  • Genetics
  • Medical Imaging

Background:

  • Autosomal Dominant Alzheimer's disease (ADAD), caused by PSEN1, APP, or PSEN2 mutations, provides a model for early Alzheimer's disease (AD) neuropathology.
  • The medial temporal lobe (MTL) is crucial for memory; however, the impact of ADAD mutations on MTL network dynamics and subfield integrity remains under-investigated.
  • Identifying early biomarkers for ADAD progression is essential for understanding disease mechanisms.

Purpose of the Study:

  • To investigate the effects of ADAD mutations on MTL network flexibility and subfield volumetric integrity.
  • To identify potential early biomarkers for ADAD progression.
  • To explore the relationship between MTL structural and functional measures and cognitive outcomes in individuals with ADAD.

Main Methods:

  • A cohort of 36 participants with ADAD mutations underwent genotyping, cognitive assessment (CASI), and 3T MRI.
  • Analysis included ANCOVA and Linear Regression, with age as a covariate.
  • Neuroimaging focused on MTL network flexibility and subfield volumes.

Main Results:

  • ADAD mutation carriers showed significantly reduced MTL network flexibility, suggesting altered dynamic connectivity.
  • No significant differences in MTL subfield volumes were observed between carriers and non-carriers.
  • Right entorhinal cortex volume positively correlated with cognitive scores (CASI), indicating preserved function.

Conclusions:

  • Reduced MTL dynamic network flexibility may serve as an early functional biomarker for ADAD, preceding structural changes.
  • Larger right entorhinal cortex volume is associated with better cognitive performance in ADAD, highlighting its protective role.
  • Integrating network-based and subfield-specific analyses, considering ADAD mutation status, is crucial for understanding disease mechanisms.