Related Experiment Video

Updated: Jan 14, 2026

Establishment of a Co-culture System of Patient-Derived Colorectal Tumor Organoids and Tumor-Infiltrating Lymphocytes (TILs)
08:42

Establishment of a Co-culture System of Patient-Derived Colorectal Tumor Organoids and Tumor-Infiltrating Lymphocytes (TILs)

Published on: June 27, 2025

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Beyond the Burden: Elevating Immunotherapy in Colorectal Cancer

Christine M Parseghian1, Madhulika Eluri1

  • 1Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
|January 13, 2026
PubMed

Insights

Targeted therapy for colorectal cancer can lead to genomic changes. High plasma tumor mutation burden (TMB) after treatment may predict immunotherapy response in metastatic disease.

Area of Science:

  • Oncology
  • Genomics
  • Immunotherapy

Background:

  • Colorectal cancers often develop genomic alterations after targeted therapy.
  • Tumor mutation burden (TMB) is being explored as a predictive biomarker for immunotherapy response in microsatellite-stable metastatic colorectal cancer.

Purpose of the Study:

  • To contextualize a recent study on high plasma TMB following targeted therapy.
  • To explore the implications of high plasma TMB for immunotherapy efficacy in colorectal cancer.

Main Methods:

  • Review and contextualization of a recent study.
  • Analysis of plasma TMB levels post-targeted therapy.

Main Results:

  • High plasma TMB was observed in patients after targeted therapy.
  • This finding has implications for predicting immunotherapy response.

Conclusions:

  • Plasma TMB is a potential biomarker for immunotherapy in metastatic colorectal cancer.
  • Further research is needed to fully understand the role of TMB in guiding treatment decisions.

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