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Published on: June 14, 2016
Cardiopathogenic T Cells Govern Progression and Functional Remodeling in Inflammatory Cardiomyopathy and Chronic
Anna Joachimbauer1, Nadine Cadosch2, Cristina Gil-Cruz1
1Department of Cardiology, University Heart Center, University Hospital Zurich, University of Zurich, Zurich, Switzerland; Institute of Immunobiology, Medical Research Center, Cantonal Hospital St. Gallen, St. Gallen, Switzerland.
None:
Echocardiographic imaging mirrors the immunopathological processes underlying the progression from acute myocarditis to inflammatory cardiomyopathy. T cell-mediated myocardial inflammation and edematous swelling in subepicardial regions at disease onset is followed by smoldering low-level myocardial inflammation or increasing cardiomyocyte loss and fibrotic remodeling. The resulting decline of cardiac function in the progressive disease is reflected and best predicted by impaired echocardiographic strain.
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