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Risk factors for bleeding from gastric antral vascular ectasia.
Sung Hyun Cho1, Jinyoung Kim1, Hee Kyong Na1
1Department of Gastroenterology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
The Korean Journal of Internal Medicine
|January 14, 2026
Summary
Gastric antral vascular ectasia (GAVE) can cause significant gastrointestinal bleeding. Liver cirrhosis, chronic kidney disease (CKD), antithrombotic use, and duodenal involvement increase bleeding risk in GAVE patients.
Area of Science:
- Gastroenterology
- Hepatology
- Nephrology
Background:
- Gastric antral vascular ectasia (GAVE) is a rare cause of gastrointestinal bleeding.
- The clinical course and risk factors for GAVE-related bleeding are not well-established.
- Recurrent bleeding from GAVE presents a therapeutic challenge.
Purpose of the Study:
- To investigate the clinical course of GAVE.
- To identify risk factors associated with GAVE bleeding and rebleeding.
Main Methods:
- Retrospective review of 348 GAVE patients diagnosed via upper GI endoscopy.
- Evaluation of clinical course and bleeding risk factors.
- Analysis of follow-up data for bleeding events and rebleeding.
Main Results:
- GAVE bleeding occurred in 35% of patients during follow-up.
- Risk factors for GAVE bleeding included liver cirrhosis (Child-Pugh B/C), chronic kidney disease (CKD), antithrombotic agents, and duodenal bulb involvement.
- CKD was a significant risk factor for rebleeding (32% of patients).
- Argon plasma coagulation was the primary endoscopic hemostasis method.
Conclusions:
- Patients with GAVE and risk factors like liver cirrhosis, CKD, antithrombotic use, or duodenal involvement require careful bleeding surveillance.
- Understanding these risk factors can guide management strategies for GAVE patients.
Keywords:
Argon plasma coagulationEndoscopyGastric antral vascular ectasiaGastrointestinal hemorrhageRisk factorsMore Related Videos
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