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Diffuse Annular Plaques in a Man in his 70s.

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Dermatologic manifestations like diffuse annular plaques can indicate underlying acute myeloid leukemia (AML). Consider leukemia skin involvement and bone marrow tests for treatment-resistant lesions.

Keywords:
acute myeloid leukemiaannular plaquesbone marrow testskin manifestation

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Area of Science:

  • Hematology
  • Dermatology
  • Oncology

Background:

  • Cutaneous manifestations can be the initial sign of hematologic malignancies.
  • Diffuse annular plaques are uncommon dermatologic presentations.

Purpose of the Study:

  • To highlight the association between specific skin lesions and acute myeloid leukemia (AML).
  • To emphasize the importance of considering leukemia in patients with persistent, unusual skin findings.

Main Methods:

  • Case presentation of a 70-year-old male with chronic, diffuse annular plaques.
  • Diagnostic workup included skin biopsy, bone marrow smear, and bone marrow flow cytometry.

Main Results:

  • The patient was diagnosed with acute myeloid leukemia (AML).
  • Skin biopsy and bone marrow analyses confirmed the diagnosis.

Conclusions:

  • Diffuse annular lesions unresponsive to eczema treatment may signal leukemia.
  • Bone marrow examination is crucial for diagnosing hematologic malignancies presenting with dermatologic signs.