Related Experiment Video

Updated: Jan 15, 2026

Development of a Neonatal Piglet Acute Lung Injury Model Recreating the Early Environment of Preterm Infant Lungs
08:58

Development of a Neonatal Piglet Acute Lung Injury Model Recreating the Early Environment of Preterm Infant Lungs

Published on: October 31, 2025

536

Evidence-based early-post natal approaches to limiting pulmonary disease in extremely low birth weight infants

Dinushan C Kaluarachchi1, Colm P Travers2, Erik A Jensen3

  • 1Department of Pediatrics, University of Wisconsin-Madison, Madison, Wisconsin.

Current Opinion in Pediatrics
|January 14, 2026
PubMed

Insights

Preventing bronchopulmonary dysplasia (BPD) in extremely low birth weight infants requires multifaceted, evidence-based strategies initiated early. A combination of perinatal interventions and postnatal care is crucial for reducing BPD incidence.

Area of Science:

  • Neonatal Medicine
  • Pediatric Pulmonology

Background:

  • Bronchopulmonary dysplasia (BPD) is a prevalent complication in extremely low birth weight (ELBW) infants.
  • The incidence of BPD is reportedly increasing, posing a significant challenge in neonatal care.

Purpose of the Study:

  • To review current evidence-based strategies for the prevention of BPD.
  • Focus on interventions initiated early in the infant's life.

Main Methods:

  • Comprehensive review of early life approaches for BPD prevention.
  • Discussion encompasses perinatal interventions, respiratory support, surfactant therapy, and fluid management.

Main Results:

  • Various strategies including perinatal interventions, respiratory support, surfactant therapy, pharmacological treatments, fluid management, PDA management, nutrition, and dietary supplements were examined.
  • No single strategy is universally effective for all at-risk infants.

Conclusions:

  • A multifaceted, evidence-based approach is essential for BPD prevention.
  • Interventions should commence during the perinatal period to mitigate BPD risk in preterm infants.
Abstract

Keywords:
bronchopulmonary dysplasiachronic lung disease of prematurityextremely low birth weight infants

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