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Precision Therapeutics Across Cancer, Immunology, and Pain
Mahmoud A Elkhalifa1, Robert B Kargbo2
1University of Pennsylvania, Philadelphia, Pennsylvania 19104-6323, United States.
Abstract:
Targeted protein degradation, next-generation antibody discovery, and spatial multiomics are reshaping therapeutic strategies across oncology, immunology, and neurology. Recent innovations include platelet-sparing degraders of BCL-XL for cancer treatment, rare antibody recovery platforms for challenging antigens, in situ sequencing for immune repertoire mapping, and senolytic PROTACs that target pain-associated neurons. Together, these approaches exemplify how mechanistic precision and synergistic platforms can accelerate therapeutic breakthroughs.
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