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Author Spotlight: Enhanced Generation of Patient-Derived 3D Organoids for Glioblastoma and Glioma
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Living Organs as Micro-Factories: Material-Producing Organoids.

Quentin M Perrin1, Ali Miserez1,2

  • 1Centre for Sustainable Materials, School of Materials Science and Engineering, Nanyang Technological University (NTU), Singapore, Singapore.

Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
|January 14, 2026
PubMed
Summary
This summary is machine-generated.

Organoids, self-organizing tissues, can sustainably produce advanced materials like spider silk. This developmental biology approach offers eco-friendly solutions for material fabrication, moving beyond traditional manufacturing.

Keywords:
biological materialorganoidself‐assemblyself‐organizationtissue engineering

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Area of Science:

  • Developmental biology
  • Material science
  • Tissue engineering
  • Nanotechnology

Background:

  • Growing demand for sustainable material production due to resource scarcity and global warming.
  • Limitations of current synthetic materials in terms of complexity, biodegradability, and environmental impact.
  • Potential of biological systems to create hierarchical materials with superior properties.

Purpose of the Study:

  • To explore developmental biology as a manufacturing process for advanced materials.
  • To highlight the potential of self-organizing tissues, like organoids, for sustainable material production.
  • To showcase spider silk as a model for organoid-based material synthesis.

Main Methods:

  • Review of developmental biology principles applied to material manufacturing.
  • Focus on self-organization in biological systems (e.g., silk glands, organoids).
  • Case study using spider silk production and hair-bearing organoids derived from induced pluripotent stem cells (iPSCs).

Main Results:

  • Biological systems naturally create hierarchical materials with enhanced mechanical properties and biodegradability.
  • Organoids, such as hair-bearing organoids, can be engineered to produce materials.
  • Spider silk serves as a model for understanding organ-based material synthesis and assembly.

Conclusions:

  • Material-producing organoids represent a nascent but promising field for sustainable, high-value product generation.
  • Interdisciplinary collaboration between bioengineers, developmental biologists, and material scientists is crucial.
  • Addressing challenges in scaling up organoid production and expanding to new species is key for future applications.