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Updated: Jan 15, 2026

Author Spotlight: Functionalizing Metal-Organic Frameworks: Advancements, Challenges, and the Power of Post-Synthetic Ligand Exchange
Published on: June 23, 2023
Coordination Complexes and Polymers of Novel Hybrid Tetrazole-Triazole-Pyrazole Ligands: Synthesis, Structural
Yousra Bahjou1,2, Youssef Draoui1, Smaail Radi1
1LCAE, Department of Chemistry, Faculty of Science, University Mohamed I, Oujda, Morocco.
Abstract:
New series of triazole/pyrazole and tetrazole/triazole/pyrazole ligands were synthesized and coordinated with various transition metals to yield a diverse library of 14 complexes. All compounds were fully characterized by elemental analysis, mass spectrometry, powder X-ray diffractometry, and a range of spectroscopic techniques (1H NMR, 13C NMR, FT-IR, and UV-visible diffuse reflectance). The crystal and molecular structures were elucidated via single-crystal X-ray diffraction, and their supramolecular features were explored through Hirshfeld surface analysis. The 57Fe Mössbauer and magnetic SQUID measurements confirmed the high-spin nature of the FeII complex 1. In the three human cancer cell lines, most metal complexes are somewhat more cytotoxic than the inactive ligands, with Co(II) complexes 2 and 8 being the most potent in two of the cell lines (with IC50 values in the two-digit micromolar range). Overall, this study highlights how blending tetrazole/triazole/pyrazole ligands with transition metals can lead to coordination compounds with potential in anticancer research, as a proof of concept. These results add valuable insight to the expanding field of metal-based therapeutics and could help guide the development of next-generation, more effective agents.
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