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Related Experiment Video

Updated: Jan 17, 2026

Using Nanoplasmon-Enhanced Scattering and Low-Magnification Microscope Imaging to Quantify Tumor-Derived Exosomes

Using Nanoplasmon-Enhanced Scattering and Low-Magnification Microscope Imaging to Quantify Tumor-Derived Exosomes

Published on: May 24, 2019

High-Sensitivity SPR Biosensor for Tumor Cell Exosome Detection Based on Ge-Doped Fiber Core PCF.

Licui Ji¹, Honggang Pan¹, Hongli Dai¹

¹Engineering Research Center of Optoelectronic Devices & Communication Technology, Ministry of Education, Tianjin Key Laboratory of Film Electronic and Communication Devices, School of Integrated Circuit Science and Engineering, Tianjin University of Technology, Tianjin, China.

Journal of Biophotonics

|January 14, 2026

Summary

This summary is machine-generated.

This study introduces a novel biosensor using germanium-doped photonic crystal fiber and surface plasmon resonance for highly sensitive exosome detection. The advanced sensor accurately distinguishes between normal, tumor-derived, and pro-metastatic exosomes for improved cancer management.

Keywords:

biosensor exosomes photonic crystal fiber surface plasmon resonance

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Last Updated: Jan 17, 2026

Using Nanoplasmon-Enhanced Scattering and Low-Magnification Microscope Imaging to Quantify Tumor-Derived Exosomes

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Author Spotlight: Engineering Molecular Tools for Disease Detection and Imaging

Published on: December 8, 2023

Area of Science:

Biomedical Engineering
Optoelectronics
Nanotechnology

Background:

Current exosome detection methods lack sensitivity and have limited refractive index (RI) detection ranges.
Exosomes play crucial roles in cancer progression and metastasis, necessitating precise detection methods.

Purpose of the Study:

To develop a high-performance, label-free biosensor for sensitive and accurate exosome detection.
To enhance early postoperative micrometastasis surveillance and improve cancer management.

Main Methods:

A D-shaped photonic crystal fiber (PCF) biosensor incorporating a germanium-doped core and gold film coating was designed.
Surface plasmon resonance (SPR) technology was employed for exosome detection.
Simulations and optimizations were performed to evaluate sensor performance.

Main Results:

The proposed biosensor achieved an extended RI detection range of 1.00-1.45 RIU.
A peak wavelength sensitivity of 30,000 nm/RIU at 1500 nm was recorded.
The sensor successfully differentiated normal (1.35-1.38 RIU), tumor-derived (1.39-1.42 RIU), and pro-metastatic (1.43-1.45 RIU) exosomes with high accuracy.

Conclusions:

The germanium-doped PCF-SPR biosensor offers a label-free, high-performance solution for exosome detection.
This technology holds significant potential for early micrometastasis surveillance and enhanced cancer management.