Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Positron Emission Tomography01:29

Positron Emission Tomography

6.2K
Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...
6.2K
Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

853
Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
853

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sub-Nyquist sampling based amplitude demodulation for resonant-mode atomic force microscopy.

The Review of scientific instruments·2026
Same author

Noncovalent Cluster Packing Enables Ultrastable Glasses for Preservation and Delivery of Labile Biomolecules.

Angewandte Chemie (International ed. in English)·2026
Same author

Amyloid Fibrillation of a Ninjurin-1-Derived α-Helical Peptide: Structural Insights into Conformational Transition.

ACS nano·2025
Same author

Mechanisms of RCD-1 pore formation and membrane bending.

Nature communications·2025
Same author

A Nomogram for Predicting Prognostic Assessment of Traumatic Intracranial Hematoma: A Retrospective Cohort Study.

World neurosurgery·2025
Same author

Dysfunction of a lepidopteran conserved gene, BmBLOC1S6, causes a translucent larval integument in the silkworm, Bombyx mori.

Pest management science·2025

Related Experiment Video

Updated: May 5, 2026

PET and MRI Guided Irradiation of a Glioblastoma Rat Model Using a Micro-irradiator
10:48

PET and MRI Guided Irradiation of a Glioblastoma Rat Model Using a Micro-irradiator

Published on: December 28, 2017

9.9K

Comparative Evaluation of Voxel-Level Dosimetry Methods in 90Y-Microsphere Radioembolization Using PET/CT.

Hai Hu1,2,3,4, Zi-Wei Liang5, Ya-Bo Zhao1,2

  • 1Center for Advanced Quantum Studies, School of Physics and Astronomy, Beijing Normal University, No. 19, Xinjiekouwai Street, Haidian District, Beijing 100875, China.

Molecular Pharmaceutics
|January 15, 2026
PubMed
Summary

The voxel S-value (VSV) method offers accurate, rapid dosimetry for Yttrium-90 microsphere radioembolization, outperforming local energy deposition and approaching Monte Carlo simulation speeds for liver cancer treatment.

Keywords:
90Y-microsphere radioembolizationMonte Carlo simulationPET/CTlocal energy deposition methodvoxel-S-value methodvoxel-level dosimetry

More Related Videos

Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform
07:57

Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform

Published on: March 24, 2022

3.1K
Y-90 Radioembolization and PD-1 Inhibitor as Neoadjuvant Treatment in Hepatocellular Carcinoma
09:11

Y-90 Radioembolization and PD-1 Inhibitor as Neoadjuvant Treatment in Hepatocellular Carcinoma

Published on: May 24, 2024

1.1K

Related Experiment Videos

Last Updated: May 5, 2026

PET and MRI Guided Irradiation of a Glioblastoma Rat Model Using a Micro-irradiator
10:48

PET and MRI Guided Irradiation of a Glioblastoma Rat Model Using a Micro-irradiator

Published on: December 28, 2017

9.9K
Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform
07:57

Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform

Published on: March 24, 2022

3.1K
Y-90 Radioembolization and PD-1 Inhibitor as Neoadjuvant Treatment in Hepatocellular Carcinoma
09:11

Y-90 Radioembolization and PD-1 Inhibitor as Neoadjuvant Treatment in Hepatocellular Carcinoma

Published on: May 24, 2024

1.1K

Area of Science:

  • Medical Physics
  • Radiology
  • Nuclear Medicine

Background:

  • Yttrium-90 (90Y) microsphere radioembolization is a standard treatment for liver cancer.
  • Accurate post-treatment dosimetry is crucial for optimizing patient outcomes.
  • Current voxel-level dosimetry methods require evaluation for clinical applicability.

Purpose of the Study:

  • To compare the accuracy and computational efficiency of three dosimetry methods: Monte Carlo (MC), voxel S-value (VSV), and local energy deposition (LDM).
  • To assess the clinical practicality of these methods for 90Y radioembolization dose verification.

Main Methods:

  • Analysis of post-treatment PET/CT data from 68 patients treated with 90Y microspheres.
  • MC simulations served as the reference standard for dosimetry.
  • VSV method involved convolving PET images with a precomputed 90Y kernel; LDM assumed complete local energy absorption.

Main Results:

  • VSV achieved near-MC accuracy with significantly reduced computation time (seconds vs. hours for MC).
  • LDM overestimated doses in high-dose regions and showed larger deviations compared to MC.
  • VSV demonstrated high agreement with MC, with small differences in mean dose and EUBED, and tighter Bland-Altman limits.

Conclusions:

  • VSV provides a clinically practical solution for rapid and reliable voxel-level dosimetry in 90Y radioembolization.
  • The VSV method combines MC-level accuracy with dramatically reduced computation time.
  • VSV may support personalized treatment evaluation and dose verification in liver cancer therapy.