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Extracorporeal Blood Purification (HA-380) in Rhabdomyolysis-Induced Acute Kidney Injury: A Successful Outcome
Marisa Cunha1, Sílvia Sousa1, Ricardo Marinho1
1Intensive Care Unit, Unidade Local de Saúde de Santo António, Oporto, Portugal.
European Journal of Case Reports in Internal Medicine
|January 15, 2026
Summary
Haemoadsorption effectively cleared myoglobin in a severe case of rhabdomyolysis-induced acute kidney injury. This extracorporeal therapy, when added to renal replacement therapy, showed significant improvement, suggesting its potential for enhancing kidney recovery.
Area of Science:
- Nephrology
- Intensive Care Medicine
- Toxicology
Background:
- Rhabdomyolysis involves skeletal muscle breakdown, releasing myoglobin into circulation.
- Elevated myoglobin is a primary cause of acute kidney injury (AKI).
- Conventional renal replacement therapies (RRT) are inefficient at clearing large molecules like myoglobin.
Purpose of the Study:
- To present a case of severe rhabdomyolysis-induced AKI managed with haemoadsorption.
- To evaluate the efficacy of haemoadsorption as an adjunct to RRT for myoglobin removal.
Main Methods:
- A patient with severe rhabdomyolysis and AKI was treated with prolonged intermittent RRT.
- A haemoadsorption device (HA-380 cartridge) was integrated into the RRT circuit.
- Plasma levels of myoglobin and creatine phosphokinase were monitored.
Main Results:
- The addition of haemoadsorption led to significant reductions in myoglobin and creatine phosphokinase levels.
- The patient experienced notable laboratory and clinical improvement.
- Haemoadsorption facilitated effective myoglobin clearance, which is poorly achieved by RRT alone.
Conclusions:
- Extracorporeal adsorption therapy, specifically haemoadsorption, can be a valuable adjunct to RRT in managing severe rhabdomyolysis-induced AKI.
- Early implementation of haemoadsorption may improve renal recovery and patient outcomes.
- Further prospective studies are needed to define optimal protocols for haemoadsorption in this setting.
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