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Related Experiment Videos

B lymphocyte antigens in sicca syndrome.

H M Moutsopoulos, T M Chused, A H Johnson

    Science (New York, N.Y.)
    |March 31, 1978
    PubMed
    Summary

    Individuals with sicca syndrome possess unique B lymphocyte antigens, unlike normal controls. These antigens suggest a potential genetic requirement for developing this autoimmune disease.

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    Area of Science:

    • Immunogenetics
    • Autoimmune Diseases
    • Human Immunology

    Background:

    • Sicca syndrome is a human autoimmune disease.
    • B lymphocyte antigens in sicca syndrome patients resemble mouse immune response-associated (Ia) antigens.
    • The genetic basis of sicca syndrome is not fully understood.

    Purpose of the Study:

    • To investigate the B lymphocyte antigens associated with sicca syndrome.
    • To compare the prevalence of these antigens in patients versus normal controls.
    • To explore the potential genetic linkage of these antigens to disease development.

    Main Methods:

    • Immunological testing of individuals with sicca syndrome.
    • Genetic analysis to determine antigen presence in patients and normal controls.
    • Comparison of findings with animal models of immune response genes.

    Main Results:

    • All sicca syndrome patients studied had two distinct B lymphocyte antigens.
    • These antigens were found in only 37% and 24% of normal controls.
    • In animal models, Ia antigen genes are closely linked to immune response genes.

    Conclusions:

    • The presence of these specific B lymphocyte antigens may be a risk factor for sicca syndrome.
    • Two specific genes associated with these antigens might be necessary for sicca syndrome development.
    • Further research into the immunogenetics of sicca syndrome is warranted.

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