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Establishment of Epstein-Barr Virus Growth-transformed Lymphoblastoid Cell Lines
Published on: November 8, 2011
HLA type of EBV-transformed human B cell lines
1Georgetown University School of Medicine, Washington, DC, USA.
Current Protocols in Immunology
|April 25, 2008
Summary
This appendix provides a list of Epstein-Barr virus (EBV)-transformed B lymphoblastoid cell lines (B-LCL) and their Human Leukocyte Antigen (HLA) types. These cell lines are valuable resources for cellular immunity research and histocompatibility studies.
Area of Science:
- Immunology
- Genetics
Background:
- Epstein-Barr virus (EBV)-transformed B lymphoblastoid cell lines (B-LCL) are widely used in immunological research.
- Characterizing the Human Leukocyte Antigen (HLA) types of these cell lines is crucial for their application.
Purpose of the Study:
- To provide a comprehensive list of reference EBV-transformed B-LCL.
- To detail the specific HLA types expressed by each listed B-LCL.
Main Methods:
- Compilation of data from established cell line repositories.
- Genotyping of B-LCL for HLA class I and class II alleles.
Main Results:
- A curated list of EBV-transformed B-LCL is presented.
- The corresponding HLA typing for each cell line is provided.
Conclusions:
- These characterized B-LCL serve as essential tools for cellular immunity studies, including antigen-specific response restriction.
- The cell lines are valuable for biochemical analysis of histocompatibility molecules and as controls in DNA-based typing methods.
