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Updated: Jan 16, 2026

Interventional Diagnostic Procedure: A Practical Guide for the Assessment of Coronary Vascular Function
10:28

Interventional Diagnostic Procedure: A Practical Guide for the Assessment of Coronary Vascular Function

Published on: March 15, 2022

5.8K

[Functional assessment of coronary artery disease in the interventional cardiology suite]

Victor Weerts1, Cédric Davidsen1, Mathieu Lempereur1

  • 1Service de Cardiologie, CHU Liège, Belgique.

Revue Medicale De Liege
|January 15, 2026
PubMed

Insights

Ischemic heart disease assessment is evolving beyond coronary angiography. New invasive and imaging-derived physiological techniques like Fractional Flow Reserve (FFR) and Quantitative Flow Ratio (QFR) offer better functional evaluation for improved patient care.

Area of Science:

  • Cardiology
  • Medical Imaging
  • Physiology

Background:

  • Ischemic heart disease (IHD), a manifestation of atherosclerotic cardiovascular disease, is a major global health concern.
  • Coronary angiography is standard for anatomical assessment but limited in evaluating lesion significance.
  • Intermediate or multivessel coronary artery disease often requires functional assessment.

Purpose of the Study:

  • To provide a practical overview of current modalities for assessing coronary lesion significance.
  • To discuss the physiological basis of invasive and imaging-derived techniques.
  • To explore the integration of these techniques into clinical interventional practice.

Main Methods:

  • Review of invasive physiological techniques: Fractional Flow Reserve (FFR), instantaneous Wave-Free Ratio (iFR), and Resting Full Cycle Ratio (RFR).
  • Discussion of emerging imaging-derived tools: Quantitative Flow Ratio (QFR) and computed tomography-derived FFR (FFRCT).
  • Analysis of the physiological principles underpinning hemodynamic evaluation.

Main Results:

  • Invasive techniques (FFR, iFR, RFR) provide objective hemodynamic assessment, crucial for intermediate lesions.
  • Imaging-derived methods (QFR, FFRCT) offer less invasive alternatives for functional evaluation.
  • These tools aid in decision-making for revascularization strategies.

Conclusions:

  • Functional assessment of coronary lesions is vital for managing ischemic heart disease.
  • A range of invasive and imaging-based tools are available, each with specific applications.
  • Integrating these modalities enhances the precision of interventional cardiology practice.

Keywords:
CoronarographyCoronary StenosisCoronary physiologyFunctional assessmentIschemic cardiomyopathy

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