A magnetic induction-based differential method for intracerebral hemorrhage lateralization.

Area of Science:

• Biomedical Engineering
• Medical Physics
• Neuroscience

Background:

• Magnetic induction technology (MIT) is a non-contact, non-invasive sensing method suitable for detecting brain lesions, unaffected by skull shielding.
• Existing MIT studies for intracerebral hemorrhage (ICH) primarily focus on presence detection or volume estimation, with limited research on spatial localization.

Purpose of the Study:

• To propose and validate a magnetic induction differential localization (MIDL) method for detecting and localizing ICH.
• To investigate the correlation between differential signal components and hemorrhage side/volume.

Main Methods:

• Designed a pair of symmetrically arranged detection coils to sense differential magnetic field perturbations.
• Verified system feasibility and response characteristics via numerical simulations and physical phantom experiments.
• Conducted in vivo validation on rabbits with induced unilateral hemorrhages.

Main Results:

• Simulations and phantom experiments showed opposite variation trends in real and imaginary signal components for left- and right-side hemorrhages.
• Animal experiments confirmed significant signal variation amplitudes (P < 0.05) exceeding baseline deviation after blood injection.
• Observed opposite signal change directions between hemispheres, correlating with hemorrhage side.

Conclusions:

• The MIDL method effectively distinguishes the hemorrhage side.
• Provides a theoretical and experimental foundation for non-invasive ICH localization using MIT.