Sticky neutrophils, risky tumors: NETs in DICER1-associated rhabdomyosarcoma
1Lester and Sue Smith Breast Center, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA; Dan L. Duncan Cancer Center, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA; Department of Molecular and Cellular Biology, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA; Graduate Program in Immunology and Microbiology, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA.
Abstract:
In this issue of Developmental Cell, Larsen, Hanna et al. show that germline Dicer1 haploinsufficiency promotes fusion-negative rhabdomyosarcoma (FN-RMS) through neutrophil accumulation and the production of neutrophil extracellular traps (NETs). This research uncovers a non-cell-autonomous mechanism of DICER1 tumor predisposition whereby NET-prone neutrophils transform the tumor microenvironment and promote tumor expansion.
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