Related Experiment Video
Updated: Jan 18, 2026
05:12
Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder
Published on: June 23, 2023
1.4K
Examining the Relationship Between Alcohol Use Disorder and Glaucoma: Protocol for a Scoping Review
Fatima Elghazali1, Alexandria Hughes1, Tracy Shields2
1Translational Biobehavioral and Health Promotion Branch, Clinical Center, National Institutes of Health, 10 Center Dr, Bethesda, MD, 20892, United States, 1 301-435-9232.
JMIR Research Protocols
|January 16, 2026
Summary
This scoping review examines the complex relationship between alcohol use disorder (AUD) and glaucoma. It aims to clarify mixed findings on how alcohol consumption impacts glaucoma development and progression.
Area of Science:
- Ophthalmology
- Addiction Medicine
- Public Health
Background:
- Alcohol use disorder (AUD) impacts various organ systems, including the eyes, with potential dose-dependent effects on intraocular pressure (IOP).
- Existing research on the alcohol-glaucoma link presents mixed findings, with limited investigation specifically within the AUD population.
- Glaucoma is characterized by optic nerve damage and vision loss, potentially influenced by systemic changes associated with heavy alcohol consumption.
Purpose of the Study:
- To conduct a scoping review synthesizing current literature on alcohol consumption, AUD, and glaucoma.
- To map existing research, identify associations between alcohol intake and glaucoma, and synthesize evidence on drinking patterns and glaucoma risk.
- To clarify the relationship between AUD and glaucoma to inform future research directions.
Main Methods:
- Systematic literature search across major biomedical databases (PubMed, MEDLINE, Embase, Web of Science, CENTRAL).
- Two-step screening process using Covidence software with independent review by two researchers.
- Data charting and evidence synthesis presented in narrative and tabular formats.
Main Results:
- The review is currently underway, initiated in November 2024.
- Data collection and submission are projected for completion between November 2025 and January 2026.
- Funding is provided by the National Institutes of Health Intramural Research Program.
Conclusions:
- This scoping review will provide a comprehensive overview of the literature on alcohol consumption and glaucoma.
- Findings are expected to clarify inconsistent research results and guide future investigations into AUD and its ocular manifestations.
- The study aims to enhance understanding of how alcohol use impacts glaucoma development and progression.
Related Concept Videos
01:25Glaucoma: Overview
1.3K
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
1.3K
01:27Open Angle Glaucoma: Treatment
963
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
963
01:28Angle Closure Glaucoma: Treatment
1.2K
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
1.2K