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Enhancing abdominal wall healing using an oriented polycaprolactone microfibrous scaffold prepared using the fiber
Michala Klusáček Rampichová1,2, Kateřina Strnadová3,4, M Plencner5
1Department of Tissue Engineering, Institute of Experimental Medicine, The Czech Academy of Sciences, Prague, Czech Republic. michala.rampichova@iem.cas.cz.
Hernia : the Journal of Hernias and Abdominal Wall Surgery
|January 16, 2026
Summary
A novel biodegradable scaffold made of aligned poly(ε-caprolactone) (PCL) microfibers enhanced abdominal wall repair in rabbits. This PCL scaffold improved tissue strength and healing, showing promise for reducing incisional hernia recurrence.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Tissue Engineering
Background:
- Incisional hernias are common after abdominal surgery, with high recurrence rates even with synthetic meshes.
- Developing improved methods for abdominal wall repair is crucial to reduce complications.
Purpose of the Study:
- To develop and assess a biodegradable, aligned microfibrous scaffold for enhanced abdominal wall repair.
- To evaluate the scaffold's potential in supporting wound healing and strengthening the abdominal wall.
Main Methods:
- Fabrication of aligned poly(ε-caprolactone) (PCL) microfibrous scaffolds using controlled fiber-drawing.
- In vitro biocompatibility testing with fibroblasts (adhesion, proliferation).
- In vivo evaluation in rabbits with abdominal wall incisions, followed by mechanical, histological, and immunohistochemical analyses.
Main Results:
- The aligned PCL scaffold demonstrated excellent in vitro cell attachment and proliferation.
- In vivo implantation significantly improved the tensile modulus of the repaired abdominal wall.
- Histological analyses showed enhanced collagen deposition and increased microvessel density in scaffold-treated areas.
Conclusions:
- The aligned PCL microfibrous scaffold effectively improved the mechanical properties and biological quality of abdominal wall healing.
- This scaffold shows potential for clinical application in reducing incisional hernia formation.
