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Related Experiment Video

Updated: Jan 18, 2026

Full-Field Optical Coherence Microscopy for Histology-Like Analysis of Stromal Features in Corneal Grafts
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Corneal endothelial cell density changes after Preserflo MicroShunt implantation.

Taro Baba1, Osamu Baba1, Kikuno Hirose1

  • 1Department of Ophthalmology and Visual Science, Hiroshima University, Hiroshima, Japan.

The British Journal of Ophthalmology
|January 16, 2026
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Summary

Preserflo MicroShunt implantation led to a reduction in corneal endothelial cell density over 12 months. Narrower tube-cornea angles and higher preoperative intraocular pressure predicted this cell loss.

Keywords:
CorneaGlaucoma

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Area of Science:

  • Ophthalmology
  • Glaucoma Surgery
  • Corneal Health

Background:

  • Preserflo MicroShunt (PMS) is a device used in glaucoma surgery.
  • Corneal endothelial cell density (CECD) is crucial for corneal transparency and function.
  • Understanding the impact of glaucoma devices on CECD is important for patient outcomes.

Purpose of the Study:

  • To evaluate the effect of Preserflo MicroShunt (PMS) implantation on corneal endothelial cell density (CECD).
  • To identify factors associated with CECD loss after PMS implantation.

Main Methods:

  • Retrospective study of 104 eyes undergoing PMS implantation (alone or with cataract surgery).
  • CECD measured preoperatively and at 3, 6, and 12 months postoperatively.
  • Linear and logistic regression used to analyze CECD change and associated factors.

Main Results:

  • Annual CECD loss was estimated at 7.3% for PMS alone and 8.0% for combined surgery.
  • A narrower tube-cornea angle (TCA) was significantly associated with greater CECD loss (p=0.01).
  • Higher preoperative intraocular pressure (IOP) was also a significant predictor of CECD loss (p=0.04).

Conclusions:

  • Preserflo MicroShunt implantation is associated with a reduction in CECD over 12 months.
  • Narrower TCA and higher preoperative IOP are significant predictors of CECD loss following PMS implantation.
  • These findings highlight the importance of considering pre-existing ocular conditions when evaluating patients for PMS implantation.